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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors investigated the optima dose (efficacy and safety) of moxisylyte, an alpha-blocking agent, in a double-blind placebo-controlled crossover study in 30 patients. The origin of the erectile dysfunction was predominantly psychological in 14 patients and neurological in 16 patients. Each patient received 4 intracavernous injections in a randomized order (placebo, 10, 20, 30 mg of moxisylyte) at 7-day intervals. Regardless of the dose, moxisylyte induced significantly greater penile responses than placebo on all erection criteria. The frequency of responses allowing sexual intercourse appeared to be dose-dependent in the two aetiological groups. The erectile responses most frequently obtained were complete rigidity in the "neurological" group and tumescence in the "psychological" group. The safety was excellent for 95.6% of injections and no case of priapism was observed. One patient (neurological patient) experienced two prolonged erections after the dose of 20 mg and another patient (psychological patient) reported 2 headaches after the dose of 30 mg. No pain was experienced on injection. Moxisylyte is very well tolerated and is able to induce an erectile response from the dose of 10 mg. This dose appears to be sufficient in patients with central neurological erectile dysfunction; a dose of 20 mg tends to improve the quality of response in patients with a predominantly psychological disorder, although the differences observed between the doses were not statistically significant in this number limited of patients.
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PMID:[Effectiveness of and tolerance to intracavernous injection of moxisylyte in patients with erectile dysfunction: effect/dose relationship versus placebo]. 858 Sep 80

Skinfold thickness and tenderness are variables that have been used in the diagnosis of headaches of cervical origin. In order to assess these variables in actual patients, the normal limits have to be properly known. Skinfold thickness and tenderness during the "skin roll" ("pinch and roll") test were, therefore, investigated simultaneously in a group of 95 healthy individuals. Three positions (trapezius, mandibular, and supraorbital areas) were used. The following values for skinfold thickness in healthy individuals during the skin roll test were obtained: trapezius position 5 to 26 mm (mean 11.2 mm, SD 3.9), mandibular 3 to 12 mm (mean 6.5 mm, SD 1.8), and supraorbital 3 to 9 mm (mean 4.6 mm, SD 0.8). Strong positive correlation was found between subject height and skinfold thickness in the mandibular position. Skinfold thickness in the mandibular (P = 0.003), as well as in the trapezius position (P = 0.023) correlated positively with age. In 13 individuals (13.7%), tenderness to a varying extent was found in the shoulders (trapezius position). No pain was recorded in the other positions. No correlation was found between skinfold thickness and tenderness (P = 0.66).
Headache 1997 May
PMID:'Skin roll' ('pinch and roll') test: skinfold thickness and tenderness. 919 66

Headache is considered as a non-specific syndrome illustrating the concept of pain as an emotion. Viewed in this way, its meaning looms larger than its site.Pain indicates dis-ease of the patient, sometimes with his body, but more often with his life. No pain is "imaginary", nor can some pain be assigned to physiological and some to psychological pathways. Such a decision is often merely a judgmental one.Just as the "brain" cannot easily be separated from the "mind", so to believe that some pain is "physical" and some "emotional" is a distortion. All painful syndromes are mixed and the problem is to decipher the meaning of the pain. Only rarely will headache respond to physical measures alone.
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PMID:PSYCHOLOGICAL ASPECTS OF HEADACHE. 1419 22