Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An interim report at six months of a post-marketing surveillance study of Euhypnos Forte, a new high-dose temazepam preparation for the treatment of insomniac patients resistant to conventional hypnotic dosage. The analysis includes 2,043 First Reports (FRs) of two weeks treatment and 669 Second Reports (SRs) of three months treatment. More than 95% of the patients took a nightly dose of two capsules, temazepam 40 mg. Adverse reactions were generally acceptable, consisting mainly of headache, vivid dreams, gastro-intestinal disturbances and hangover effects. The preparation was effective in 88.6% of patients at two weeks and 95.8% at three months. All patients had previously found other hypnotics ineffective. Euhypnos Forte was rated effective by 85.5% of the 874 patients who had previously found nitrazepam unsatisfactory, and by 90.0% of the 201 who found barbiturates unsatisfactory.
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PMID:Euhypnos Forte (temazepam) for resistant insomnia: post-marketing surveillance, an interim report. 4 Aug 39

One hundred and forty-seven patients requiring a hypnotic, took soft gelatine capsules containing 10 mg temazepam (Euhypnos) 10-30 mg at night, for up to twelve weeks. One hundred and thirty-three patients (90-5%) completed twelve weeks on drug. Hypnotic performance was rated Good or Very Good in 90% of their assessments and 93-2% of the assessments recorded no hangover effect. Adverse reactions were occasional headaches and nausea. There were no drug-related accidents. One hundred and forty-two patients (96-6%) said there was no adverse effect on their work. Seven patients who did not complete twelve weeks resumed normal sleep patterns and had no further need for hypnotics.
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PMID:Temazepam (Euhypnos) as a hypnotic: a twelve-week trial in general practice. 91 56

We assessed the lifetime prevalences of headache disorders in a cross-sectional epidemiologic survey of a representative 25- to 64-year-old general population. We classified the headaches on the basis of a clinical interview and a physical and neurologic examination using the operational diagnostic criteria of the International Headache Society. Lifetime prevalence of idiopathic stabbing headache was 2%, of external compression headache 4%, and of cold stimulus headache 15%. Benign cough headache, benign exertional headache, and headache associated with sexual activity each occurred in 1%. Lifetime prevalence of hangover headache was 72%, of fever headache 63%, and of headache associated with disorders of nose or sinuses 15%. Headaches associated with severe structural lesions were rare. External compression headache, fever headache, headache associated with metabolic disorders, and headache associated with disorders of nose or sinuses all showed significant female preponderance. The symptomatic headaches and headaches unassociated with structural lesions were more prevalent among migraineurs. In subjects with tension-type headache, only hangover headache was overrepresented. There was no association between the headache disorders and abnormal routine blood chemistry or arterial hypertension. In women with migraine, however, diastolic blood pressure was significantly higher than in women without migraine.
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PMID:Symptomatic and nonsymptomatic headaches in a general population. 160 51

Although many of us don't like to admit it, most of us have experienced the unmistakeable feeling of "the morning after." Dry mouth, nausea, dizziness, and headache are just a few of the consequences of overindulgence. Medically, this is known as acute alcohol withdrawal, but to us it's just a hangover.
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PMID:Alcohol consumption and hangover. 227 69

A post-marketing surveillance study of Euhypnos (temazepam), a new short-acting benzodiazepine hypnotic. A total of 12,350 patients requiring a sleep inducer were treated for up to 3 months with doses of 10-30 mg at night. After 2 weeks 80% of First Reports (FRs) rated Euhypnos effective and at 3 months this had risen to 92% of 3062 Second Reports (SRs). Hangover was reported in 7% of FRs and 2% of SRs but in general the drug was well tolerated with adverse reactions consisting mainly of morning nausea, headache, drowsiness and vivid dreaming. Eighty-seven per cent of FRs and 93% of SRs were 'Clean' reporting no hangover, adverse reaction or event of any kind.
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PMID:Post-marketing surveillance of Euhypnos (temazepam): a new hypnotic. 610 82

A post-marketing surveillance study of Euhypnos Forte (temazepam 20 mg) capsules for the treatment of insomnia in 10,057 patients previously unresponsive to other hypnotics given in conventional doses. Patients were prescribed a nightly dose of 40 or 60 mg, but 95% actually took 40 mg. At 2 weeks, 89% of patients found the treatment effective, as did 95% at 3 months. Hangover, severe enough to stop treatment, occurred in less than 3% of patients, and other adverse reactions such as headache, dreams, gastrointestinal disturbance and hangover symptoms were reported by only 6% of patients at 2 weeks and 4% at 3 months. The most common reason for stopping treatment was the patient having no further need for hypnotics. Euhypnos Forte was effective in 88% of 3,800 patients who had found nitrazepam unsatisfactory and 90% of 1,013 patients unresponsive to barbiturates.
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PMID:Euhypnos forte, high dose temazepam for resistant insomnia: post-marketing surveillance in 10,057 patients unresponsive to conventional hypnotic dosage. 610 67

During a double-blind clinical study, a new hypnotic benzodiazepine, lormetazepam (Wy 4082), was compared at a fixed dose of 1 mg to sodium amobarbital at a fixed dose of 100 mg for the treatment of moderate insomnia in 2 groups of 25 psychiatric outpatients. The medication was given at bedtime and the duration of the study was limited to 2 weeks. The quality of sleep was evaluated by the patient after the first night and at the end of the first and second week and by investigator at the end of the 2 weeks trial. The two products appeared effective on global assessment, but with an advantage in favour of lormetazepam: earlier onset of sleep and excellent acceptability on the final evaluation. Fifty two per cent of patients treated with amobarbital had side effects, mainly hangover and sedation during the morning, while only one patient treated with lormetazepam complained of headaches in the morning.
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PMID:[Lormetazepam and amobarbital in the treatment of insomnia in psychiatric outpatients. A controlled study]. 612 88

Tolfenamic acid (TA), a potent inhibitor of prostaglandin (PG) biosynthesis and action, was tested prophylactically against hangover symptoms in 30 healthy volunteers in a double-blind cross-over study. One capsule of TA (200 mg) or placebo was taken before starting to drink alcohol and another before going to bed. The hangover symptoms were evaluated in the morning. TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p less than 0.001) and in reducing the reported hangover symptoms in general (p less than 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p less than 0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p less than 0.05). In a separate study with eight participants, plasma levels of PGs were followed during ingestion of alcohol with or without TA. The plasma concentrations of PGE2 and TXB2 (a metabolite of thromboxane A2) were lower in the TA group during alcohol ingestion, while PGF2 alpha and 6-keto-PGF1 alpha (a metabolite of prostacyclin) were unaffected. TXB2 correlated with blood alcohol levels in a U-shaped manner.
Cephalalgia 1983 Mar
PMID:Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid. 634 13

A survey of women undergoing pregnancy termination as 1-day outpatients (8 AM-6 PM) asking for their reactions after recovery in hospital and during the following day at home was prompted by a study which revealed unexpectedly high subsequent morbidity among a group of outpatient abortion cases. 65 patients were given a questionnaire and 50 were returned. Anesthesias used for operations studied were thiopentone, diazepam, pethidine, atropine with ergometrine, and methohexitone (obese patients were given halothane as supplement to nitrous oxide and oxygen). The survey bias was toward discovering any anesthetic-related sequelae. 86% of responders reported being well on the journey home. 52% resumed activities on the first postoperative day. 96% recollected preoperative advice of not eating or drinking and 94% remembered being told not to drive. Only 34% of patients were driving, cooking, or operating machines by the second postoperative day. 50% felt confident to do so, however. 2% consumed alcohol on the first postoperative day but none reported an increased effect. As an outpatient only 6% would be happy to receive the same anesthetic; 88% would take it as an inpatient. 70% found the anesthetic favorable vs. 2% who did not. 88% found hospital stay favorable vs. 2%. 20% had developed headache or drowsiness the day after surgery. Anesthesias which don't cause such a high rate of hangover effect should be developed for these 1-day outpatient procedures.
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PMID:The acceptability of day stay for termination of pregnancy. 730 56

The effectiveness of ramped hypertonic sodium dialysis (RHSD) is controversial because of the prevalence of side effects (weight gain and hypertension). Standard dialysis (SD) was therefore compared with RHSD in a double-blind controlled crossover trial. Eleven patients who suffered from symptoms attributable to water shifts from extracellular fluid to intracellular fluid (headaches or hangover) or extracellular-fluid volume contraction (cramps or lightheadedness) and five asymptomatic patients were enrolled in the study. RHSD was individually tailored to each patient (to minimize thirst) during a 2-wk run-in period. Patients then received RHSD and SD for a period of 3 wk in randomized sequence. Outcome measures were both objective and subjective ratings on questionnaires. Significant differences were found between the two treatments, with RHSD improving specific problems (70% of lightheadedness/cramps, 100% of headaches/hangover) versus SD. Weight gain and hypertension were not different between the two treatments despite increased thirst sensation reported by 14/16.94% of patients preferred RHSD. Long-term studies in 20 different patients demonstrated the lack of increase in blood pressure or weight gain after 3 and 6 months of therapy.
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PMID:The benefits and side effects of ramped hypertonic sodium dialysis. 898 53


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