Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although destructive bone disease is a well-known complication of tertiary syphilis, osteitis or osteomyelitis are not commonly recognized as complications of early (primary or secondary) syphillis. A patient with secondary syphilis characterized by generalized lymphadenopathy, perianal condyloma lata, and positive rapid plasma reagin (RPR) and fluorescent treponemal antibody-absorption (FTA-ABS) tests also complained of headache, right should pain, and right anterior chest pain and swelling. Roentgenograms showed mottled osteolytic lesions consistent with previously described luetic bone disease. Biopsy confirmed the diagnosis of syphilitic osteomyelitis, and treatment with penicillin resulted in prompt resolution of symptoms.
 ...
PMID:Destructive bone disease in early syphilis. 103 40

Following an introduction on the notion of posttraumatic headache and on the etiology and pathogenesis of headache occurring after head injuries, the author discusses in detail the clinical aspects of such pain. Especially, a description of headache that can be expected in different types of head injury and posttraumatic complication, is presented. The importance of differential diagnosis of cephalea originating in the vertebro-cervical region and of atraumatic headache occurring casually some time after a head injury, is stressed. In the author's view, genuine chronic posttraumatic cephalea exists only in very rare cases and is always associated with considerable organic intracranial lesions. As to treatment, long-standing continuous medication with analgesics is strictly rejected. The usual therapeutic measures are mentioned and judged critically. For prophylaxis of chronic headache following head injuries, adequate primary treatment, early mobilization and early return to occupational activity seem most important. Long-lasting confinement to bed in the absence of objective clinical signs is considered as one the causes of obstinate cephalea after head injuries which are frequently only minor in degree. If psychoneurotic fixation of the accident sets in, psychiatric treatment should be commenced immediately as to prevent the establishment of irreversible neurotic symptoms. For the same reason, a pending procedure for recompensation should be settled as soon as possible. Observing the therapy explained, including guidance of patients, the prognosis of headache following head injuries proves on the whole to be very favourable.
 ...
PMID:[On the so-called posttraumatic headache (author's transl)]. 104

Chronic vague abdominal pain is an extremely common complaint in children over 5 years, with a peak incidence in the 8 to 10 year group. In over 90 per cent of the cases no serious underlying organic disease will be discovered. Most disease states can be ruled out by a careful history, a meticulous physical examination, and a few simple laboratory tests such as urinalysis, sedimentation rate, hemoglobin, white blood count determination, and examination of a blood smear. If organic disease is present there are often clues in the history and the examination. The kidney is often the culprit--an intravenous pyelogram should be done if disease is suspected. Barium enema is the next most valuable test. Duodenal ulcers and abdominal epilepsy are rare and are over-diagnosed. If no organic cause is found, the parents must be convinced that the pain is real, and that "functional" does not mean "imaginary." This is best explained by comparing with "headache"--the headache resulting from stress and tension hurts every bit as much as the headache caused by a brain tumor or other intracranial pathology. Having convinced the patient and his parents that no serious disease exists, no further investigation should be carried out unless new signs or symptoms appear. The child must be returned to full activity immediately.
 ...
PMID:Abdominal pain in children. 104 83

It appears that a uniform "psychosomatic headache" does not exist. This is due to 1. the variety of phenomenology, 2. the variety of causes and 3. the variety of results in the psychodiagnostic and psychotherapeutic field. Analysis of the factors active in headache was attempted in a field study and on the basis of a systematic survey of many years of clinical experience. Within the framework of the concept of multifactorial causation of headaches we found 3 particularly important factors: vasolability, depression and the cervical spine. From the psychodynamic situation disturbing factors appear to be able to produce or maintain headache in this way. Physical examination by itself without taking psychodynamics into account will have to be called just as incomplete as an approach based exclusively on depth psychology alone. The questions on endogeneicity versus exogenicity have to be thought about both from points of phenomenology and individual analysis of the psychodynamic background of every patient, as part of a complex concept of treatment. Headache as an early sign of schizophrenia is rare but should not be forgotten. Among the many factors causing headache it is by no means always clear what is cause and what effect. Often there appears to be interaction which continues in the end autonomously or increases. It has been described on the example of the painspiral in the region of the cervical spine. For diagnosis we try to determine the various pathogenic factors via an anterospective program of examination. This will serve as the basis for our "targetted polypragmasia" i.e. we attempt to influence at one and the same time many of the factors which have been recognized as pathogenic. Drugtherapy apart we favor somatic vegetative stimulation. The results of our field study (strong preponderance of headaches among the non-manual professions together with clinical experience) support our view that in this way we enter an etiologically highly effective circuit. The effectiveness of phsychotherapy lies for the greater number of headache-patients within the zone of initial clearance, less in the direct action on the syndrome of pain. As main therapy psychotherapy has proved effective only in individual cases of predominantly psychogenic headache. We could also discuss the role of neuroleptic sleep cures which soothe psychologically and act also biochemically. No short-cuts and no sound simple prescriptions for the treatment of headache could be given. But the author hopes to have contributed to understanding of a complex field which may result in multi-layered but also clearly defined factors and their more effective therapy.
 ...
PMID:[Interaction of phsychologic and somatic factors in headache (author's transl)]. 104 59

Epileptic paroxystic headache consists of an episode of pain that starts suddenly, in a varying area that is usually the same for the same patient, of medium to high intensity, lasting from a few seconds to minutes and, rarely, hours; the episode subsides spontaneously and tends to recur. This was found in 32 of 125 patients studied by the author. Average age of onset was 11 years, with 80% of cases presenting it in the first or second decade of life. Once diagnosed, the condition was present a maximum of 41 years and a minimum of one month, with an average of six years. Headache lasted from 30 seconds to 4 hours; in 62% of cases it was 15 minutes or less. Pain was severe in 24 patients and moderate in 8. Epileptic paroxystic headache can be the only epileptic symptom (31%) or be associated with other ictal manifestations, independently (56.2%) or simultaneously (12.5%). EEG studies showed focalization in temporal lobe (56%), in the midbrain (12.5%) or in other areas. Treatment with hydantoine, primidone and methylsuccimide gave excellent results. Differential diagnosis with other paroxystic headaches is noted.
 ...
PMID:[Paroxysmal epileptic headache]. 105 18

A screening examination for the assessment of tempormandibular joint dysfunction was evaluated in a series of 279 patients. Tenderness upon palpation of one or more of the muscles of mastication and/or pain upon retrusion of the mandible was noted in seventy-nine patients (28 per cent). These objective signs of temporomandibular joint dysfunction did not correlate statistically with maximum opening of the mouth, age, taking of analesics or tranquilizers, headache or dizzy spells, crepitus, and the patients dental condition.
 ...
PMID:The feasibility of a screening procedure regarding temporomandibular joint dysfunction. 105 37

With the aid of questionnaires symptoms of mandibular dysfunction and some general and oral conditions were studied in a group of previous patients and in a randomly selected population sample. From the two materials answers were obtained from 82 persons (81%) and 1.106 (91%) respectively. The results confirmed that women are heavily overrepresented in patient materials. This differs from the fairly equal sex distribution found in population studies of mandibular dysfunction. The most frequent symptoms of mandibular dysfunction were TMJ-sounds which appeared in 39 and 79% and pain on opening the mouth which appeared in 12 and 42% of the population and patient samples respectively. All symptoms of mandibular dysfunction, headache, clenching of the teeth and unilateral chewing appeared significantly more often in the previous patients, but the number of natural teeth did not differ in the two samples. The general state of health was poorer and general joint -- muscle symptoms were more common in the previous patients as well as in those of the population sample with symptoms of mandibular dysfunction. This finding suggests that functional disturbances of the masticatory system often may be related to impaired general health.
 ...
PMID:Symptoms of functional disturbances of the masticatory system. A comparison of frequencies in a population sample and in a group of patients. 106 19

Transcutaneous administration of a slightly painful electrical stimulus was employed in the management of migraine and other forms of headache in 35 patients with various pictures of pain. Stimulation during crisis led to its total disappearance in 6 subjects with migraine. A relatively high percentage of successes was noted in the remaining patients, with persistence up to 8 months. The theory of "gate control" is cited to explain this effect. Stress is laid on the particular suitability of the method in the management of chronic headache, since it is not associated with either dependence or toxic medicamentous effects.
 ...
PMID:[Transcutaneous nervous stimulation in the treatment of hemicrania and other forms of headache]. 108 1

Nineteen patients obstinate with cluster headaches whose pain was not mitigated by standard treatment (Methysergide, caffeine, ergotamine preparation, phenobarbital and analgesics) underwent a double blind control study with single crossover for the evaluation of prednisone therapy. Compared to placebo, a single oral dose of prednisone in 17 cases produced sustained improvement. Maintenance administration of prednisone was also effective in decreasing the frequency of attacks; however a single dose of the steroid when headaches began was effective.
 ...
PMID:The treatment of cluster headaches with prednisone. 109 22

Pathologic examination in a case of fatal intracerebral hemorrhage from a berry aneurysm showed that the "sentinel" or warning headache in this patient was due to the leakage of blood into the subarachnoid space through a previous small tear in the wall of her saccular aneurysm. Oribital pain, transient, dysphasia, dizziness and, later, meningismus might have prompted the performing of a lumbar puncture to determine the presence of blood in the cerebrospinal fluid. This type of event is the likely pathogenetic mechanism for the premonitory headache that may precede a lethal rupture of a saccular aneurysm.
 ...
PMID:Pathogenesis of the "sentinel headache" preceding berry aneurysm rupture. 110 29


<< Previous 1 2 3 4 5 6 7 8 9 10