Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We review here the literature on neuroendocrine neoplasms metastatic to the pituitary and present an example of the disease. Metastasis of bronchial carcinoid tumors to the sellar region are rare. Herein, we describe the case of a 63-year-old woman who presented with constant cough and headaches. She had previously been operated for carcinoid tumor of the lung. During the preoperative investigation, a CT scan of the head revealed a sellar mass. Six months after a left lower lobectomy, the sellar lesion was removed by transsphenoidal surgery. The two tumors were evaluated by histology, immunohistochemistry and electron microscopy. Both showed identical morphologic features, those of carcinoid tumor. Immunohistochemistry revealed immunoreactivity for the endocrine markers, synaptophysin and chromogranin, as well as CD-56, serotonin, bombesin and vascular endothelial growth factor. The sellar neoplasm showed nuclear immunopositivity for thyroid transcription factor-1, supporting the diagnosis of a metastatic bronchial carcinoid tumor. In conclusion, this is the first report of a serotonin- and bombesin-immunopositive atypical bronchial carcinoid tumor metastatic to the sella.
 ...
PMID:Bronchial carcinoid tumors metastatic to the sella turcica and review of the literature. 2248 18

The authors present the case of a 58-year-old gentleman presenting with atypical carcinoid tumor of primary lung origin metastasizing to a previously identified pituitary macroadenoma. The patient presented with symptoms of headache and visual disturbance. Imaging revealed enlargement of a known sellar mass as well as three separate enhancing lesions in the brain parenchyma. Resection was accomplished via a transnasal transshpenoidal approach without complication. Immunoreactivity was demonstrated to synaptophysin, chromogranin, CD56, epithelial membrane antigen, and thyroid transcription factor-1. The specimen was also marked by negative staining for pituitary hormones. This case demonstrates a rare occurrence of metastastic spread of tumor to a previously identified pituitary macroadenoma.
...
PMID:Carcinoid tumor of the lung metastatic to a previously identified pituitary adenoma. 2496 Jul 52

The metastasis of cancer to the pituitary gland is uncommon but may mimic a typical pituitary adenoma. Such cancers often derive from the breasts or the lungs, or very rarely from thyroid carcinoma. We described the case of a 60-year-old woman who presented with headaches and pain to the right eye. CT and MRI scans of the head revealed a sellar mass compressing the optic chiasm and invading the cavernous sinus. Her serum prolactin level was 1720 mIU/L. The preoperative diagnosis was pituitary adenoma. An endoscopic endonasal transsphenoidal approach was used to remove the tumor. Immunohistochemistry revealed immunoreactivity for thyroid transcription factor-1, CK-7, TG, supporting the diagnosis of a metastatic thyroid carcinoma. The rechecked thyroid ultrasonography showed a nodus with calcification on the left side. A total thyroidectomy was performed with a final histopathological diagnosis of minimally invasive follicular thyroid carcinoma. She was advised to take 131I treatment. The relevant literature is reviewed in light of this unusual case, illustrating the problems in the diagnosis and management of this type of patient.
 ...
PMID:Minimally invasive follicular thyroid carcinoma mimicking pituitary adenoma: a case report. 3193 88