Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mycoplasma pneumoniae is a common causative agent of community acquired pneumonia. To assess its epidemiological, clinical and evolutive features in our area, we retrospectively analyzed 88 instances which occurred during 10 years. Both sexes were similarly involved, with a higher incidence in younger patients (mean age: 22 years). A clear seasonal predominance was not detected during the study period. In nearly one half of instance there were similar respiratory episodes in the same household. Cough was a constant symptom, followed by fever and headache. The absence of leukocytosis and the presence of cryoagglutinins were suggestive data. Pulmonary infiltration in the chest radiogram was unilateral in most cases, with a segmental distribution and predominating in the lower lobes. Hilar lymph nodes, pleural effusion and cavitation were present in a limited number of instances. All patients were cured without sequelae. The occurrence of particular epidemiological, clinical and laboratory data may be very helpful in suggesting the diagnosis of pneumonia due to Mycoplasma pneumoniae.
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PMID:[Pneumonia caused by Mycoplasma pneumoniae]. 249 Apr 46

An epidemic of Q fever in Berlin affected at least 80 patients (45 females, 35 males; age range 1-75 years). Sheep were identified as the focus of infection: they had been brought to a veterinary clinic because of nonspecific symptoms. The peak incidence of the infection was in April and May, 1992. Most of the patients were staff or students at the veterinary clinic. This is the most northern and, at the same time largest, Q fever epidemic recorded in Germany over the last 28 years. The complement fixation reaction (CFR) was not helpful diagnostically in the acute stage of the disease as it remained negative in the first 14 days (CFR < or = 1:5). Most of the patients had sudden fever to over 40 degrees C, severe headache and dry cough. Pulmonary infiltrates were seen in the chest radiograph of 8 of the 10 patients presented in this contribution. Auscultation was largely negative. Two patients had signs of hepatic involvement (GPT as high as 71 U/l). The drug of choice was doxycycline at a dosage of 200 mg twice daily for 14 days.
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PMID:[A Q fever epidemic in Berlin. The epidemiological and clinical aspects]. 850 Apr 12

Legionnaire's disease (LD) is a non-zoonotic atypical community acquired pneumonia (CAP) with several characteristic extra-pulmonary findings. Pending diagnostic test results, selected characteristic findings when considered together are the basis of clinical syndromic diagnosis and the basis of empiric antimicrobial therapy. Of the extra-pulmonary manifestation of LD, neurologic findings are among the most common, e.g., headache, mental confusion. In LD, encephalitis is rare as are myoclonus and seizures. This is a most interesting case of LD that presented with encephalitis, myoclonus and seizures. Pulmonary infiltrates developed early after admission. LD was suspected on the basis of otherwise unexplained characteristic findings, e.g., hypophosphatemia, elevated serum transaminases, microscopic hematuria, elevated ferritin, and empiric doxycycline therapy was started. The diagnosis of LD was further supported by prominent and persistent myoclonus and seizures, rare but characteristic neurologic findings in LD. On week 12 of hospitalization, he finally seroconverted with negative urinary antigen tests indicating his LD was due to a non-L. pneumophilia (serotype 01) strain. On doxycycline, he made a slow but complete recovery. We believe this is the first reported case of LD presenting with encephalitis, myoclonus, and seizures successfully treated with doxycycline.
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PMID:Legionnaire's disease presenting with encephalitis, myoclonus, and seizures: Successful treatment with doxycycline. 3138 57