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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 5-year-old boy presented with a 7-month history of headache and projectile vomiting. Computerized axial tomography revealed a large, high density lesion involving the entire left frontal lobe. At operation a 330-g, apparently encapsulated, mildly cystic neoplasm was removed from the region of the left frontal operculum. Microscopic examination demonstrated moderately cellular astrocytic tissue interspersed with several large, bizarre, and occasionally binucleate ganglion cells. The pathological entity of ganglioglioma is briefly reviewed.
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PMID:Ganglioglioma--neurogliogenic tumor involving the left frontal lobe: case report. 50

A 14-year-old boy presented with cerebellar ganglioglioma manifesting as severe headache and confusion. Computed tomographic scans showed a huge, partly enhanced cystic cerebellar tumor. The tumor was totally removed. Histological examination disclosed glial cells and mature ganglion cells. The latter were identified by Nissl's staining and immunostaining for neurofilaments. Ganglion cells were present in the cerebellum and the surrounding subarachnoid space. This heterotopic growth of ganglion cells enabled a firm diagnosis of cerebellar ganglioglioma.
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PMID:Cerebellar ganglioglioma--case report. 172 26

A case of cerebellar ganglioglioma in a 5 year-old girl is presented. She came to our hospital on January 30, 1989 with complaints of headache of one year duration. CT scans disclosed a low density lesion suggesting a cystic tumor in the left cerebellar hemisphere with moderate hydrocephalus. Preoperative MRI demonstrated more clearly the location and extent of the tumor. She was operated on using suboccipital craniotomy, on March 3. Subtotal removal of the tumor was performed because the tumor had invaded the brain stem. She made an uneventful recovery without any neurological deficits. Histologically, the tumor was composed of ganglion cells and astrocytic cells, so it was diagnosed as ganglioglioma. Cerebellar ganglioglioma is a rare tumor, and only 17 cases have been reported including the present case. Clinical and radiological study of these cases revealed that there are no specific findings to indicate cerebellar ganglioglioma and preoperative diagnosis is impossible. But practically, MRI is the most sensitive method for identifying the extent of the lesion and, thus, is of benefit for deciding operative strategy.
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PMID:[Cerebellar ganglioglioma: a case report]. 223 8

A case of cerebellar ganglioglioma is reported. A 22-year-old female was admitted to the Kurume University Hospital on August 19, 1985, suffering from headache, vomiting and gait disturbance. On admission, neurological examination revealed staggering gait and the right cerebellar ataxia showing dysmetria and dysdiadochokinesis. Mild choked disc in the right fundus was also noted. Plain CT scan showed the low-density area involving the right cerebellar hemisphere and the part of the vermis with internal hydrocephalus. Enhanced CT scan showed the high-density area adjacent to the low-density area suggesting a mural nodule. A vertebral angiogram in the arterial phase showed an expansive lesion in the posterior fossa and the tumor stain, which was also visualized in the venous phase. An emergency suboccipital craniectomy was then performed. With opening the tense dura mater, the cyst formation was noted and 30 ml of xanthochromic fluid was then aspirated. A well demarcated mural nodule was noted in the lateral wall of the cyst. The nodule was then extirpated in toto. The hypertrophy of the cerebellar cortex was not observed. Histologically, the tumor was consisted of nerve fiber, glial fiber and neuronal cells. Its architecture was differed distinctly from that of hamartomatous diffuse hypertrophy of the cerebellar cortex (Lhermitte-Duclos' disease). Immunohistochemically, the neuronal cells revealed positive staining for NSE and S-100, and the glial cells displayed positive staining for GFAP, S-100. The authors reviewed previously reported eleven cases of cerebellar ganglioglioma including the present case. These results showed that cerebellar gangliogliomas have some characteristic clinical features among general intracranial gangliogliomas.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Cerebellar ganglioglioma: a case report]. 304 1

Gangliogliomas are relatively rare tumors of the CNS in which ganglion cells and neuroglia coexist. 13 cases are reported, representing 0.61% of a series of 2,121 patients undergoing biopsy for CNS tumors. The clinical, radiological, pathological, electron microscopical and immunohistochemical features were evaluated with clinical follow-up. The age of the patients ranged from 3 to 51 years, including 8 males and 5 females. Duration of symptoms prior to surgery varied from 15 days to 12 years, the most common symptoms being seizures, headache, vomiting and motor disturbances. Computed tomographic scans found high density space-occupying mass in 6 patients and low density space-occupying mass in 3. Ten of the tumors originated form the cerebral hemispheres and three from the midline. The tumors were all sharply delineated and well defined from surrounding tissues. The tumor is generally firm. 8 patients are survived operation for 2-10 years. Neurons and glial cells in the tumor could be demonstrated by electron microscopy and immunohistochemical examination. Anaplastic transformation in the gliomatous component was found in one case. This series suggest that surgical removal of this neoplasm carries a good prognosis.
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PMID:[Clinicopathology of gangliogliomas]. 816 79

The authors present the case of a 10-year-old boy admitted for evaluation of a generalized seizure and a history of headaches. Computerized tomography (CT) and gadolinium-enhanced magnetic resonance (MR) imaging demonstrated a large nonhomogeneous contrast-enhancing mass of the left frontal lobe, with a large cystic component. Cerebral angiography revealed the lesion to be highly vascular and fed entirely by the internal carotid artery system. The patient underwent craniotomy and the lesion was completely removed. Neuropathological study revealed that the tumor was a ganglioglioma. On review of the literature, it was found that gangliogliomas often present in the second and third decade, are known to have cystic components, and are contrast-enhancing on CT and MR imaging; however, they are classically known to be avascular on angiography. This case of a markedly vascular ganglioglioma emphasizes that these tumors should be included in the differential diagnosis of vascular supratentorial lesions.
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PMID:Ganglioglioma presenting as a vascular lesion in a 10-year-old boy. Case report. 824 60

We describe a composite glio-neuronal tumor comprising pleomorphic xanthoastrocytoma (PXA) and ganglioglioma identified in a left temporal biopsy. The 32-year-old male patient underwent surgery following a clinical history of persistent headaches of 6 years' duration. Immunohistochemical double labeling with antibodies to synaptophysin, beta-tubulin isotype III, GFAP and CD44H demonstrated neoplastic neurons and astrocytes in the ganglioglioma, while coexpression of glial and neuronal markers was found in a subset of PXA tumor cells variously showing giant cell or spindle cell morphology. There were gradual transitions between the two neoplastic populations. These findings raise the possibility of ganglioglioma having evolved by differentiation of bipotential PXA tumor cells along astrocytic and neuronal lineages. The PXA may, therefore, be closely related to desmoplastic neuroepithelial tumors of infancy, a group of neoplasms of presumed embryonal origin.
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PMID:Pleomorphic xanthoastrocytoma with gangliogliomatous component. 952 Oct 20

We report a case of ganglioglioma located in the body and frontal horn of the right lateral ventricle. The lesion was found in a 71-year-old man who suffered from recurrent episodes of right hemicranial headache. CT and MRI showed a heterogeneous intraventricular tumour with multiple microcysts that suggested a diagnosis of subependymoma or central neurocytoma, but the pathological findings were consistent with ganglioglioma. Although the most frequent intracranial location of ganglioglioma is the temporal lobe, any location in the central nervous system may be seen. Nevertheless an exclusively intraventricular location is exceptional. To our knowledge this is the first complete radiological report of a purely intraventricular ganglioglioma.
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PMID:Intraventricular ganglioglioma: case report. 968 26

We present the case of a 8-years-old boy, admitted with a history of headache, nausea and vomiting. Cerebral angiography showed a non-vascular mass on frontal lobe. The patient underwent craniotomy and the lesion was removed. Neuropathological study revealed that the tumor was a ganglioglioma. The patient received pos-operative radiotherapy. On follow-up, 16 years after, a computed tomographic scan showed a recurrence of the tumor, and a second surgery revealed a glioblastoma multiform. Gangliogliomas are rare tumors of the central nervous system containing neoplastic ganglion cells and low grade neoplastic glial cells. The malignant degeneration occurs only in the glial component, so the prognosis of these tumors is related to the grade of that component.
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PMID:[Malignant course of a ganglioglioma: case report]. 975 34

An 11-year-old boy's epileptic seizures started with a feeling of impending crisis, dizziness, headache, and a bad taste in the mouth. This was followed by swallowing and a burning sensation in the left hand. At the same time, other parts of the body experienced allodynia. MRI and CT scans showed a right anteromesial temporal lesion which proved at neuropathology to be a ganglioglioma. Lesionectomy resulted in complete cessation of seizures. Seizures were absent at an 18-month follow-up. Allodynia is discussed in relation to the locality of the lesion.
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PMID:Painful seizures with allodynia in an 11-year-old boy. 1058 48


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