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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cogan syndrome is a multisystem inflammatory vascular disease, characterized by nonsyphilitic interstitial keratitis and vestibuloauditory symptoms. Recent reports have directed attention to involvement of other organ systems. Respiratory, cardiovascular, gastrointestinal, and musculoskeletal problems are common, as are laboratory abnormalities and general symptoms such as fever, chills, and weight loss. Prominent neurologic problems in two patients prompted a review of 79 cases of Cogan syndrome. More than half had nervous system involvement, including electroencephalographic or spinal fluid abnormality, headache, psychosis, coma, convulsion, neuropathy, and stroke. Cogan syndrome should be considered when neurologic deficits are accompanied by eye, ear, and systemic symptoms.
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PMID:Neurologic manifestations of Cogan syndrome. 30 11

Cogan's syndrome is a rare autoimmune multisystem disease. The main clinical features of typical Cogan's syndrome are vestibuloauditory dysfunction and interstitial keratitis. The authors present a case of atypical Cogan's syndrome with headache, fever, deafness, trigeminal neuralgia and electroencephalographic abnormality which mimicked viral encephalitis.
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PMID:Atypical Cogan's syndrome mimicking encephalitis. 1530 93

Cogan's syndrome (CS) is an autoimmune disorder characterized by non-syphilitic interstitial keratitis and progressive audiovestibular impairment. Haynes et al. modified diagnostic criteria for patients with other ocular or vestibular symptoms and suggested this to be atypical CS. We report the case of a 71-year-old man with atypical CS. He was referred to our hospital with a headache, bilateral facial nerve palsy, left episcleritis and bilateral sensorineural hearing loss. Serological test results for syphilis and antineutrophil cytoplasmic autoantibodies were negative. Cerebral MRI revealed sinusitis and pituitary swelling. Contrast-enhanced computed tomography (CT) of the aorta demonstrated thickening of the wall and stenosis of the aorta with pathological uptake on fluorodeoxyglucose positron emission tomography. Biopsy of the sinus mucosa exhibited angiitis of the arterioles, capillaries, and venules. Atypical CS was diagnosed on the basis of episcleritis, progressive sensorineural hearing loss and exclusion of other inflammatory diseases. Intravenous injection of 500mg/day methylprednisolone for 3 days was effective for alleviating the patient's symptoms, except for hearing loss, but the disease recurred during the tapering of prednisolone (PSL). Combined therapy with PSL (10 mg/day) and methotrexate (6 mg/week) helped achieve remission of the disease. CS is causative of cranial polyneuropathy, but diagnosis of the former is not always straightforward as in the cases of cranial polyneuropathy. It has been considered that CS is a subtype of polyarteritis nodosa (PN); however, the clinical signs and size of the affected vessels in the present patient are different from those in PN. It is postulated that CS is a vasculitic syndrome that should be distinguishable from PN.
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PMID:[A case of atypical Cogan's syndrome with a steroid-responsive headache and multiple cranial neuropathy as the initial symptoms]. 2198 70

Cogan's syndrome (CS) is a chronic inflammatory disorder of unknown etiology that most commonly affects young adults. Clinical hallmarks are bilateral interstitial keratitis and vestibuloauditory dysfunction. Association between CS and systemic vasculitis as well as aortitis also exists. The diagnosis of CS is based upon presence of characteristic inflammatory eye disease and vestibuloauditory dysfunction. We describe classic Cogan's syndrome in a 47-year-old female from Ardabil. The patient was admitted with headache, vertigo, nausea, vomiting, right leg claudication, musculoskeletal pains, bilateral hearing loss, and blindness for the past two months. Ophthalmologic examination revealed that visual acuity was 0.1 bilaterally. Conjunctival hyperemia, bilateral cataract, and interstitial keratitis were detected with a slit lamp examination. Pure tone audiogram (PTA) and auditory brain stem response (ABR) showed bilateral sensorineural hearing loss. The other differential diagnosis of CS was studied and ruled out. Pulse i.v. methylprednisolone and cyclophosphamide were given and were followed by oral prednisolone and cyclophosphamide. Clinical follow-up showed partial improvement.
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PMID:Interstitial Keratitis, Vertigo, and Vasculitis: Typical Cogan's Syndrome. 2471 22