Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective study of 72 consecutive and nonrandomized patients with malignant glial tumors is presented. The influence of age, sex, location of tumor, initial presenting symptoms, symptomatic preoperative interval, reoperation, extent of tumor removal, histological subtype of tumor, lymphocyte infiltration, and different treatments upon survival time has been evaluated and statistically analyzed. Age was inversely associated with survival with a strong statistical significance (p = 0.0001). Headache was the most common (67%) initial symptom; aphasia and seizure were both present in 45.3% of patients. Initial presenting symptoms had no effect upon survival. Parietal lobe and lymphocyte infiltration had marginally negative effects upon survival (p = 0.097 and p = 0.10 respectively). The amount of tumor removal was marginally associated with an improved survival (p = 0.07). Radiation therapy was strongly associated with an improved survival time (p = 0.0007). The addition of chemotherapy did not affect the survival (perhaps reflecting the small number of patients and inadequate chemotherapy). There was an obvious beneficial effect of reoperation upon survival time, if the patient lived and underwent reoperation later than 16 months after the initial operation (slow-growing tumor). Although median and mean survival times (10 and 20.34 months respectively, SD 7.45 months) were similar to most series reported, our rates of survival (20%, 12.5%, and 7.5% at 2, 3, and 5 years, respectively) were notably higher.
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PMID:Malignant gliomas of the brain. A retrospective study. 373 21

We describe the rare occurrence of an Actinomyces meyeri cerebral abscess in a 55-year-old woman following a dental extraction. This patient presented with a 2-day history of hemisensory loss, hyper-reflexia and retro-orbital headache, 7 days following a dental extraction for apical peridonitis. Neuroimaging showed a large left parietal abscess with surrounding empyema. The patient underwent craniotomy and drainage of the abscess. A. meyeri was cultured. Actinomycosis is a rare cause of cerebral abscess. The A. meyeri subtype is particularly rare, accounting for less than 1% of specimens. This case describes an unusually brief course of the disease, which is usually insidious. Parietal lobe involvement is unusual as cerebral abscesses usually have a predilection for the frontal and temporal regions of the brain. Although there are no randomised trials to guide therapy, current consensus is to use a prolonged course of intravenous antibiotics, followed by 6-12 months of oral therapy.
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PMID:Actinomyces meyeri brain abscess following dental extraction. 2587 Feb 13