Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case is described of a 23-year-old female patient presenting with unilateral proptosis, headaches, and transient epiphora. Surgery revealed an encapsulated tumour composed exclusively of spindle-shaped cells within a richly vascularised myxoid stroma. Immunohistochemical staining showed focal positivity for smooth muscle actin, vimentin, and glial fibrillary acidic protein. These combined findings are interpreted as providing evidence of a myoepithelioma, which may be regarded as a monomorphic adenoma consisting solely of myoepithelial cells. To our knowledge this is only the second report of such a tumour in the lacrimal gland.
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PMID:Myoepithelioma of the lacrimal gland: report of a case with spindle cell morphology. 132 39

Three grown-up males with a long-lasting history of rather uniform, unilateral headache in the ocular-periocular area, in cluster fashion, are examined. Pain paroxysms of short duration (15-60 sec) appear up to 5-30 times per h. The headache is unilateral without side shift. Conjunctival injection appears at the very beginning of the attack and is partly massive, lasting the entire duration of the attack, and fading away at the end of it. Tearing (massive), forehead sweating (subclinical) and rhinorrhea, all on the symptomatic side, accompany the attack. In the youngest patient, the headache became chronic after clustering for six months initially, and after approximately 3 1/2 years it became bilateral. However, even in this patient, a clear unilateral pain preponderance prevails, and the autonomic disturbances are all on the original pain side. Attacks can partly be precipitated by chewing, eating (e.g. citrus fruits), moving the head, etc. The headache is completely refractory to drug therapy, including indomethacin.
Cephalalgia 1989 Jun
PMID:Shortlasting unilateral neuralgiform headache attacks with conjunctival injection, tearing, sweating, and rhinorrhea. 1519 4

Rhodamine B is a red colored dye that is used in cosmetic products. We report a case of 17 patients who were exposed to aerosolized Rhodamine B inside a maintenance shop. The mean duration of exposure was 26 minutes (range 2-65). Sixteen of the patients (94%) complained of acute symptoms including: burning of the eyes (82%), excessive tearing (47%), nasal burning (41%), nasal itching (35%), chest pain/tightness (35%), rhinorhea (29%), cough (29%), dyspnea (29%), burning of the throat (24%), burning/pruritic skin (24%), chest burning (12%), headache (6%), and nausea (6%). All of the patients had resolution of their symptoms within 24 hours (less than 4 hours in 63%). Acute exposure to Rhodamine B resulted in transient mucous membrane and skin irritation without evidence of serious sequellae.
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PMID:Acute exposure to rhodamine B. 344 24

The 'idiopathic' dacryostenosis has not yet been cleared up in its aetiological aspects. For further explanation of aetiology and pathomechanisms an experimental, anatomical study was made. Its object was to define the angles and measurements within the bony lacrimal structures and to establish possible connections between the development of the postsaccal stenosis and certain bony constellations of the lacrimal system. The main goal of these examinations was to determine the angle between the lacrimal fossa and the main direction of the nasolacrimal canal, as well as the angles which are found in the course of the nasolacrimal canal. Macerated half skulls obtained from anatomical dissection courses were used for this study. After cleaning the bony lacrimal passages, the distal orifice of the nasolacrimal canal was closed with bone wax. The canal and the lacrimal fossa were filled with epoxy resin. After hardening the preparations were radiographed in order to make sure that the whole system was completely filled with resin. Then the surrounding bone was removed chemically and the resin casts were laid free. They were photographed and the photographs were traced and measured. A trigonometric method was then used for constructing the maximum angle between the lacrimal fossa and nasolacrimal canal. This angle was mainly directed dorsomedially and showed a considerable amount of variation. A bony system with a large angle increases the possibility of acquiring a postsaccal dacryostenosis. The bony angle is one of many factors facilitating an ascending inflammation in the lacrimal mucosa. Clinically we have to differentiate the acute, fresh dacryocystitis from the chronic, recurrent dacryocystitis. The main symptoms are epiphora, pain and inflammation in the medial canthal area and headache. The most important diagnostic examinations are the slitlamp examination of the eyelids, of the lacrimal puncta and of the anterior segment of the globe, the 'lacrimal punctum excursion test', the diagnostic rinse of the lacrimal passages, the dacryocystography and the rhinological examination. The result of a successful treatment of the acute, beginning dacryocystitis is to open the incomplete, transitory, distal stenosis of the nasolacrimal duct. The stenosis is caused by an ascending inflammation from the nose and by the swelling of the lacrimal mucosa. The blockage can be solved by massage after application of vasoconstrictory drops. The therapy of a complete, postsaccal lacrimal stenosis always has to be a dacryocystorhinostomia externa ('Toti-operation'). The Kaleff-Hollwich modification proved successful and is extended by a fibrin sealing method.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:The postsaccal, idiopathic dacryostenosis--experimental and clinical aspects. 378 Mar 77

Tearing of the retinal pigment epithelium (RPE) can complicate its detachment in the course of senile macular degeneration. In the majority of cases, there is progression to the formation of a macular fibrous scar with poor visual outcome. There have not been any previous reports of vitreous hemorrhage complicating RPE tear. We describe the findings in a 65-year-old man who was observed pre- and posttearing of a serous RPE detachment. He was receiving chronic aspirin therapy for recurrent headaches and developed a vitreous hemorrhage five weeks following the RPE tear.
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PMID:Retinal pigment epithelium tear as a cause of vitreous hemorrhage. 400

The purpose of this study has been to establish a battery of tests of autonomic functions: Quantification of submandibular/sublingual salivation, nasal secretion and tearing on both sides. The tests were performed in a control group of 20 healthy students. We used a parasympathomimetic drug, pilocarpine 0.1 mg/kg body weight, to stimulate the different secretory functions. Saliva was collected with a pair of dentistry spiral suctions. Tearing was assessed with Schirmer's test tapes. Nasal secretion was quantified using Schirmer's test tapes, too. Nasal secretion and salivation on average was fairly symmetrical, whereas there was some asymmetry in tearing (which may be artificial). In single individuals, there may be considerable asymmetry in salivation as well. This test battery will be used in the study of possible autonomic dysfunctions in patients with unilateral headache.
Cephalalgia 1983 Sep
PMID:Quantification of salivation, nasal secretion and tearing in man. 662 81

An osteoma is a slow growing, bony tumor which forms in the sinuses of the skull. Presenting complaints include headaches, cerebral symptoms, or visual disturbances, depending upon the location of the tumor. This paper describes an unusual case of ethmoid sinus osteoma, with epiphora as the primary symptom; it also caused the failure of a previous dacryocystorhinostomy. This case illustrates the need for thorough evaluation of epiphora, including sinus x-rays.
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PMID:Ethmoidal sinus osteoma--a primary cause of nasolacrimal obstruction and dacryocystorhinostomy failure. 672 1

A 37-year-old man had epistaxis, headache, intermittent swelling of the periorbital region, proptosis, epiphora, and chronic sinusitis. X-ray films showed marked erosion of the midline facial bones, total opacification of both maxillary sinuses, and clouding of the sphenoid and left ethmoid sinuses. He also had a cutaneous-maxillary sinus fistula and a purulent discharge. A histopathologic examination disclosed areas of acute and chronic inflammation with occasional noncaseating granulomas. Biopsy specimens and postoperative sputum cultures grew Mycobacterium tuberculosis, although the patient had no obvious signs of systemic disease. Because tuberculosis of the orbit is rare in developed countries, it is often overlooked in the diagnosis of granulomatous inflammation of the orbit. This can lead to exacerbation of the disease by corticosteroid treatment.
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PMID:Orbital tuberculosis. 678 99

Erythroprosopalgia is characterized by severe unilaterally and periodically occurring attacks of headache. During these fits of pain there is an increase in blood flow in the homolateral eye, conjunctival injection and epiphora. Males aged between twenty and forty are most frequently affected. The clinical picture, therapy and differential diagnosis of this disease are discussed.
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PMID:[Erythroprosopalgia or cluster headache]. 687 54

The styloid process is a slender spike-like bony process that is attached to the base of the skull that has been of interest to physicians for centuries. From this process is the attachment for five structures--three muscles and two ligaments are attached to it. Any of these soft tissues of the styloid process are prone to be torn due to trauma by way of detachment of the periosteum from the bone. These lesions may occur from auto accidents, falls, sports injuries, to prolonged medical or dental procedures requiring excessive mouth opening. The detachment of Sharpey's fibres results in the release of noxious chemicals such as kinins, histamines, prostaglandins, etc, which can produce a withdrawal reflex, causing muscle tension, ischaemia, spasm and pain. Pain transmission via C fibres may induce a host of autonomic responses as well. We have observed 11 common pains and symptoms that are associated with soft tissue lesions of the styloid process and stylomandibular ligament. They are (1) headaches localised in the anterior temporal fossa, (2) sore throat and difficulty swallowing in the absence of inflammation, (3) pain radiating to the temporomandibular joint and ear, (4) voice alteration, (5) dry, non-productive cough, (6) pain in the masseter muscle, (7) restricted mandibular opening or the "closed lock", (8) development of the "open lock", (9) sinusitis, congested stuffy nose or post nasal drip, (10) tinnitus, and (11) excessive lacrimation and bloodshot eyes. A few drops of local anesthetic into the styloid process and stylomandibular ligament attachment can temporarily relieve the pain and symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Temporal headaches and associated symptoms relating to the styloid process and its attachments. 760 81


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