Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018681 (headache)
 56,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The number of clinic consultations for condylomata acuminata (genital warts) has increased substantially during the last 30 years. Most infections produce benign lesions but a few types may be associated with cervical and penile cancers. Interferons (IFN) have shown antiviral properties to these infections and IFN-beta in particular has demonstrated a specific cytopathic effect in humans. A total of 124 patients with condylomata acuminata, the majority of whom had failed previous therapy, were treated intralesionally with either recombinant human interferon-beta la (r-hIFN-beta-1a) or placebo. Up to 6 lesions were treated in each patient, and injections were made 3 times per week for a total of 9 injections. The patients were then followed up for 3 months. Efficacy assessments at all time points (day 19, week 6 and month 3) showed a clear advantage for the r-hIFN-beta-1a interferon-beta treatment. Patients receiving r-hIFN-beta-1a showed a greater proportion of treatment success in terms of the complete or partial reduction (at least 50%) of the total area of the treated lesions. The treatment was also well tolerated. Headache, flu-like symptoms and asthenia were more common in patients receiving r-hIFN-beta-1a, but these adverse events were generally mild in severity and rarely led to patient withdrawal. It was concluded that r-hIFN-beta-1a has good efficacy in condylomata acuminata, and therefore presents a useful therapeutic alternative in this hard-to-treat condition.
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PMID:Recombinant human interferon-beta in the treatment of condylomata acuminata. 931 Feb 21

Monthly disease summary sheets from 1986-1992 of 60 dispensaries, clinics and hospitals in Narok district, Kenya were reviewed for the occurrence of brucellosis and other diseases with "flu-like symptoms". Diseases with these symptoms accounted for about 52% of the 1,037,875 cases reported for the time period. These were classified as malaria (79.3%), rheumatism (7.1%), PUO (2.4%), and brucellosis (0.8%). Brucellosis was diagnosed by a positive Rose Bengal (RB) test routinely conducted in seven out of the 60 health units. In these units, 55% of flu-like cases were classified as malaria and 21.2% as brucellosis. Individual case records of patients at four dispensaries using the RB test during 1991-92 were assessed for specific predictor symptoms. For 625 RB tested patients, a positive test result was associated with joint pain, headache, and the combinations of joint pain with headache and lameness with headache. A logistic regression model correctly predicted the RB test result in 62.3% of the time. For the 465 patients examined by the blood smear examination, identification of malaria parasites was associated with, headache, joint pain and combinations of emesis with pale mucous membranes. This regression model correctly predicted positive results 67.2% of the time. Both models indicate that selected clinical predictors represented significantly increased odds of being positive to the respective tests. However, for both diseases, clinical signs alone appear insufficient for reliable diagnosis and differentiation probably due to resemblance in symptomatology between these two and other diseases.
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PMID:Criteria for better detection of brucellosis in the Narok District of Kenya. 933 12

In October 1993 and 1994, respectively, 77 and 76 third-year veterinary students visited a swine farm to work with pigs for 3 h. On both occasions, a large number of students reported flu-like symptoms after the visit. To further investigate this, the students were presented with a questionnaire modeled after the standard questionnaire used for evaluating organic dust exposure. General and/or respiratory symptoms were reported by 103/142 (72.5%) students. General symptoms, such as eye irritation, headache and tiredness were experienced by 60/103 (42.2%) students. Cough, nasal and throat irritation, and sinus trouble were the most prevalent respiratory symptoms and were reported by 94/103 (91%) of the students. Symptoms mostly developed the same day and disappeared within 3 d after exposure. The presence of respiratory and/or general symptoms was not significantly different between students who wore a mask during the lab or those who did not. Students with pre-existing allergies were more likely to develop respiratory symptoms than non-allergic students.
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PMID:Health problems in veterinary students after visiting a commercial swine farm. 944 39

We conducted this study to address concerns regarding a perceived increase in bronchitis, skin rashes, and diarrhea and long term health effects in workers at two Refuse Derived Fuel (RDF) processing plants. We abstracted medical records to assess symptom occurrence, and to identify spirometry and lab abnormalities. Overall FEV1 and FVC showed no decrease over time for workers with more than five years of exposure. The primary self reported symptoms were low back pain and headaches followed by skin rashes, colds, 'flu', hay fever and ear problems. Conclusions from this analysis are limited by lack of standardized protocols or a control group. However, results from this analysis pointed out potential occupational health problems among RDF workers for future epidemiological and environmental studies.
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PMID:Health impairments among refuse derived fuel workers. 950 32

To evaluate the extent and motivations of self-medication, a survey was conducted among 376 adolescents aged 15 to 20 using both written questionnaires and face-to-face interviews. 84% reported having taken some drug during the preceding 15 days, 57% on their own initiative. The most frequently cited drugs were analgesics, vitamins, homeopathy and anti-inflammatory drugs. Psychotropics had been taken by 7% (as self-medication by 3%). Street drugs, mainly cannabis derivatives, had been taken by 18%. The most usual indications for self-medication were headaches (42%), influenza-like syndromes (31%), school-related stress (21%), fatigue (19%) and mood concerns (15%). Most drugs were obtained from family reserves. A multivariate analysis showed self-medication to be associated with complaints regarding headaches, past drug dependency, concerns about illegal drugs or family interactions, recent respiratory illness, and diurnal somnolence. Self-medication increased with age. There was no relationship between self-medication and gender, citizenship, parental education level, or parental drug taking. Nor was self-medication related to knowledge about pharmaceuticals, assessed by specific questions. These results support the interpretation of self-medication mainly as a learned response to psychic/somatic ill-being. An optimal utility/risk ratio for self-prescribed drugs would require public health action and global involvement of practitioners.
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PMID:[Self medication by the adolescent]. 954 Jan 42

During the past 4 years, several case reports have been published on the withdrawal syndrome which may be observed after acute interruption of a treatment with selective serotonin reuptake inhibiting antidepressants (SSRI). Paroxetine is the most frequently cited antidepressant in the literature, whereas fluoxetine is the less frequently cited of this type of drugs. The withdrawal symptoms appear a few days after stopping treatment or after a decrease of the dose. The typical symptoms are of the gastro-intestinal type, such as loss of appetite, nausea, vomiting, diarrhea and abdominal cramps. Other symptoms are sensation of instability, vertigo, dizziness, headache, malaise, muscular pains, asthenia, as well as a syndrome of pseudo-influenza. Brief electric shocks throughout the body, which last one or two seconds, have also been reported. A case is reported in detail by the authors, who observed some of these symptoms in a patient after stopping his treatment with paroxetine. This withdrawal syndrome may be due to a rebound phenomenon of the serotonergic systems after interruption of the treatment with SSRIs. It is, therefore, recommended that treatment with SSRIs is progressively stopped over a period of several weeks.
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PMID:[Withdrawal syndrome caused by selective serotonin reuptake inhibitors: apropos of a case]. 954 42

Polymer fume fever is a self-limiting condition with influenza-like symptoms (fever, headache, dry cough, dyspnoea and myalgia). It is caused by inhalation of toxic products released by combustion of fluoro-carbon polymers. There is no causal treatment, and the symptoms usually clear up spontaneously within 24 hours. This article describes an accident where 13 soldiers became ill when exposed to fumes released from a tent oven painted with a coating containing fluoro-carbons.
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PMID:[Polymer fume fever[]. 956

In the United States, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) represent two clinically indistinguishable yet epidemiologically and etiologically distinct diseases caused by Ehrlichia chaffeensis and a bacterium similar or identical to E. equi, respectively. Infection with these emerging tickborne pathogens results in acute, influenza-like illnesses with fever, headache, malaise, and frequently leukopenia and/or thrombocytopenia. Connecticut and New York have initiated statewide laboratory-based surveillance to determine the magnitude and geographic extent of ehrlichiosis. This report summarizes results from the first 3 years of surveillance, which showed that rates of ehrlichiosis were similar in counties in both states where the disease occurs, and highest age-specific rates occurred among persons aged >40 years.
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PMID:Statewide surveillance for ehrlichiosis--Connecticut and New York, 1994-1997. 964 34

In a phase I safety and immunogenicity study, 112 healthy adult volunteers were randomly allocated to receive a new bivalent (A/Texas/36/91[H1N1-like], B/Harbin/7/94) split virion influenza vaccine propagated in Madin-Darby Canine Kidney cell culture or an identical vaccine manufactured using currently licensed egg propagated virus technology. Soreness at the injection site was common but generally mild (75% of the cell culture-derived vaccine group and 62.5% of the egg-derived vaccine group; p = not significant). General reactions were less common; headache was the most frequently reported adverse effect (26.8 and 30.4%, respectively; p = not significant). Geometric mean haemagglutination inhibition titres post-immunization against the A/Texas strain were 1012 reciprocal dilution in the cell culture-derived vaccine group and 790 in the egg-derived vaccine group; against the B/Harbin strain titres were 420 and 447, respectively (all comparisons, p = not significant). It is concluded that the cell culture-derived split virion influenza vaccine is safe and immunogenic in healthy adult volunteers.
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PMID:Safety and immunogenicity of a new influenza vaccine grown in mammalian cell culture. 968 98

We report the case of a 35-year-old woman who developed headache and psychosis and gradually became comatose within 3 weeks after a flu-like infection. MRI revealed bifrontal demyelination consistent with acute disseminating encephalomyelitis (ADEM). Two different cerebrospinal fluid samples were positively tested for Legionella cincinnatiensis by direct sequencing of a PCR-amplified Legionella-specific fragment. This result made it possible to interpret the initial symptoms as Pontiac fever. We think it most likely that this is a case of ADEM following the very rare situation of a systemic infection with L. cincinnatiensis. A review of the literature on Legionella-associated encephalopathy suggests that some of these cases may also have had ADEM.
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PMID:Acute disseminated encephalomyelitis following Pontiac fever. 974 76


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