Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018133 (graft-versus-host disease)
 18,032 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Endogenous factors originally found in the bone marrow (BM) and facilitating the engraftment of xenogeneic (rat) BM in lethally irradiated mice have been recently identified as transferrins (Tf). Tf have been separated and purified from plasma pools of inbred Rii/2 rats and injected in lethally irradiated BALB/c and C57BL/6 mice 1 h before the infusion of BM and for several days after BM transplantation. Other groups of irradiated mice have been similarly treated with human Tf, Tf from other strains of rats different from the BM donors and with human or rat serum albumin. A remarkable facilitation of BM engraftment and a durable graft-versus-host disease (GVHD)-free hemopoietic chimerism have been achieved in the irradiated mice when a combination of BM and Tf from the same donor rat (Rii/2) strain was used for transplantation. Durable survival and persistent chimerism were not observed in the control groups. It seems that donor Tf profoundly affects the outcome of BM transplantation when combined with donor BM. These results indicate that the mechanism by which Tf promotes engraftment of xenogeneic BM deserves investigation in order to improve this novel procedure and to extend it to other species and possibly to man.
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PMID:Donor-derived plasma transferrin facilitates the engraftment of xenogeneic (rat) bone marrow in irradiated mice. 883 16

Successful engraftment of hematopoietic stem cells requires a supportive hematopoietic stromal microenvironment (HSM). Defects in the HSM associated with aplastic anemia, myelofibrosis, or caused by intensive ionizing radiation and chemotherapy generally result in failure of bone marrow (BM) engraftment. Transplantation of donor BM within donor HSM may therefore provide optimal conditions for allogeneic BM transplantation. We have transplanted donor hematopoietic cells together with their own HSM to improve acceptance of allogeneic or xenogeneic BM. The non-myeloablative treatment used induced tolerance to murine allografts and provided conditions for the life-long acceptance of allogeneic HSM. Allogeneic BM transplanted within it's own HSM under the kidney capsule caused less graft-versus-host disease than BM transplanted i.v. Tolerance in mice to xenogeneic (rat) HSM was less complete. Ectopic ossicles were small and contained fewer hematopoietic cells. However, simultaneous transplantation of rat BM and HSM to preconditioned mice improved engraftment of rat BM compared with transplantation of BM alone. Donor hematopoietic cells survived longer on their own HSM than on HSM of recipients.
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PMID:Transplantation of allogeneic or xenogeneic bone marrow within the donor stromal microenvironment. 1057 77