Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018133 (
graft-versus-host disease
)
18,032
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Intestinal Na
+
-nutrient cotransport depends on claudin-2 and
claudin-15
mediated Na
+
recycling. Expression of these proteins is coordinately regulated during postnatal development. While expression of claudin-2 and
claudin-15
has been studied in inflammatory bowel disease (IBD) and celiac disease (CD), it has not been assessed in other malabsorptive diseases, and no reports have compared expression in children and adults. We used quantitative immunofluorescence microscopy to assess claudin-2 and
claudin-15
expression in duodenal biopsies from children and adults with malabsorptive disease and healthy controls. Consistent with previous work in rodents, claudin-2 expression in healthy children was markedly greater, and
claudin-15
expression was less, than that in adults. Claudin-2 expression was increased in adults with CD and downregulated in children with
graft-versus-host disease
(
GVHD
). In contrast,
claudin-15
expression was reduced in adults with
GVHD
and common variable immunodeficiency (CVID). These data show that one of the two Na
+
/water pore-forming claudins is upregulated in CD and downregulated in
GVHD
and CVID. The specific claudin whose expression changes, however, reflects the age of the patient (child or adult). We conclude that contributions of claudin-2 and
claudin-15
to pathophysiology of and responses to diarrhea in children and adults with
GVHD
and CVID differ from those in CD and IBD.
...
PMID:Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease. 3160 16
