Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018133 (graft-versus-host disease)
 18,032 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using immunohistological techniques, leucocytes were enumerated in portal tracts and bile duct epithelium in bone marrow transplant recipients with and without evidence of hepatic graft versus host disease (GvHD) and compared with normal subjects. Samples were obtained 8-169 days after transplantation. In marrow recipients without graft versus host disease (GvHD), inducer and suppressor/cytotoxic lymphocytes were reduced in number in the portal tracts compared with normal subjects. In GvHD, suppressor/cytotoxic lymphocytes were increased relative to non-GvHD recipients, but did not exceed normal values, while inducer cell numbers remained low. Natural killer cells (HNK1+) were not found in normal subjects, were present in small numbers in non-GvHD transplant cases and significantly increased in GvHD. The total number of portal tract leucocytes was not elevated in GvHD and the changes in the relative proportions of cells were similar to those that have been observed in the peripheral blood after transplantation. There was no increase in the number of lymphocytes expressing the activation markers Tac, T10 and HLA-DR nor in the number of leucocytes within the bile duct epithelium itself. These findings differ from those we have previously obtained in a similarly treated group of patients with cutaneous GvHD where lymphocytes were increased in the epithelium and stroma and expressed activation markers. Like the epidermis of the skin, however, the bile duct epithelium showed increased staining for HLA-DR antigens in all cases, but focal staining was also present in four of the seven marrow recipients without GvHD. The significance of these findings is discussed.
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PMID:An immunohistological study of human hepatic graft-versus-host disease. 391 Mar 17

Various T cell subsets were characterized by double immunofluorescent staining using monoclonal antibodies (MoAb) in blood, bone marrow (BM) and tissues of 29 patients after allogeneic BM transplantation (BMT). In an attempt to prevent graft versus host disease (GvHD), 15 patients received cyclosporin A (Cy A). In the remaining 14 patients the BM was pre-incubated with a MoAb, OKT3. The regeneration of T4+ subset was delayed and the level of T8+ cells was abnormally high even 1 year after engraftment. This did not have any predictive value for the appearance of complications such as GvHD or severe viral infections. The number of T8+ cells was lower in the group of patients who received Cy A than in the OKT3 group (0.7 +/- 0.2 vs 1.5 +/- 0.3 X 10(9)/1 at day 90). In contrast to normal individuals, the T4/T8 ratio in both blood and regenerating BM of BMT patients was less than 1. A sizeable subset of circulating T cells expressed the phenotype T8+, T10+, HNK-1+, DR+. Circulating cells of this phenotype were transiently very high (up to 50%) in patients with active GvHD or suffering from severe viral infection. This subpopulation of lymphocytes was not found in the epidermal infiltrate that accompanied GvHD where the predominant phenotype was T8+, T1-, T10-, HNK-1-, DR-. We conclude therefore that after BMT the number and phenotype of circulating T cells reflects the T cell distribution seen in the regenerating BM.
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PMID:T cell regeneration after allogeneic bone marrow transplantation. 635 7