Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018133 (graft-versus-host disease)
 18,032 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Potentially immunocompetent cells have been found in washed liquid-stored red blood cells, in washed liquid-stored red blood cells to which a 40% W/V glycerol concentration was added, and in washed red blood cells freeze-preserved with 40% W/V glycerol at -80 C. A glycerol concentration of 40% W/V in an ionic medium, in addition to its cryoprotective effect on red blood cells, has a damaging effect on leukocytes. The freeze-thaw-wash process appears to produce the most damage to leukocytes and the remaining lymphocytes can be categorized into two groups: one that is capable of responding to phytohemagglutinin (PHA), and one that is not. Our study confirmed the presence of PHA-responsive lymphocytes in red blood cells freeze-preserved with 40% W/V glycerol in an ionic medium at -80 C. Although the relative proportions of these cells were variable and the results of the study somewhat erratic, we continue to recommend that liquid-preserved and freeze-preserved red blood cells be irradiated before transfusion to patients in whom graft-versus-host disease is a possible complication.
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PMID:The immunocompetence of residual lymphocytes at various stages of red cell cryopreservation with 40% w/v glycerol in an ionic medium at -80 C. 68 95

A 25-year-old woman with severe aplastic anemia received allogeneic bone marrow transplantation from an HLA-identical sibling. Pretransplant conditioning comprised 3.6 Gy of total body irradiation and 200 mg/kg cyclophosphamide. Cyclosporine (CSP) and methotrexate were administered to prevent graft-versus-host disease (GVHD). The patient complained of severe headache soon after CSP administration on day-1. On day 3, convulsion developed and she lost consciousness for 15 min. CT and MRI demonstrated low density areas and high signals, respectively, in the frontal and parietooccipital lobes and splenium of the corpus callosum, suggesting brain edema probably induced by CSP. After immediate withdrawal of CSP, glycerol and prednisolone were instituted, and the patient's condition improved. Thereafter, she developed grade II acute GVHD. This was treated with tacrolimus, which produced no adverse effects including central nervous system (CNS) toxicity. This case illustrates that careful management of CNS disorders induced by CSP can be important in patients undergoing allogeneic bone marrow transplantation.
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PMID:[Tacrolimus administration to a patient with cyclosporine-induced encephalopathy after allogeneic bone marrow transplantation]. 1102 Sep 82