Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018133 (graft-versus-host disease)
 18,032 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To assess whether the type of immune suppression in patients with hematologic malignancies affects the appearance of invasive pulmonary aspergillosis (IPA) on computed tomography (CT), we retrospectively reviewed the CT findings of 66 consecutive patients who were diagnosed with hematologic malignancies and IPA and correlated the findings to patients' IPA risk factors. In our study these risk factors included neutropenia (n = 34, 52%), stem cell transplantation (SCT; n = 30, 45%), graft versus host disease (GVHD; n = 22, 33%), and steroid use (n = 29, 44%). Nodular lesions were the most common finding on CT (n = 54, 82% of the entire patient population). These were seen in 74% of neutropenic patients (n = 25, P > 0.07), 87% of patients following SCT (n = 26, P > 0.35), 95% of patients with GVHD (n = 21, P = 0.04)), and 83% of those receiving steroids (n = 24, P > 0.45). The hypodense sign was often seen in patients without GVHD (n = 17, 39%; P = 0.003). Tree-in-bud opacities were often observed in patients who underwent SCT (n = 10, 33%; P = 0.03). Thus, peripheral nodular lesions are the most common initial finding of IPA in patients with hematologic malignancies, regardless of the mechanism of immunosuppression.
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PMID:Influence of host immunosuppression on CT findings in invasive pulmonary aspergillosis. 2010 93

Recipients of the different types of transplantation are at high risk of infection. Nosocomial infections predominate in patients who have undergone haematopoietic stem cell transplantation during the early post-engraftment period (30-100 days after the infusion); the incidence of infection is higher in graft-versus-host disease. Nodular lesions can appear in the lungs due to invasive fungal infection. A diffuse pattern is usually secondary to viral infection or P. jirovecii pneumonia. After the first 100 days a moderate risk of infection by conventional and opportunistic infections persists, such as late CMV infection. Advances in surgical techniques and the use of calcineurinics have reduced mortality from infections in recipients of solid organ transplantations. Nosocomial infections are common during the first month; opportunistic infections that are dependent on cellular immunity are more common between the first and the sixth month, from the sixth month the risk lowers and community-based infections similar to those of immunocompetent patients predominate.
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PMID:[Infections in immunocompromised patients (II). The transplanted patient]. 3228 6