Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018133 (
graft-versus-host disease
)
18,032
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A single intraperitoneal injection of 1000 mg/kg body weight of a
PCB
mixture (Aroclor 1242) to adult male BALB/cc mice caused not only a relative spleen enlargement, but also an absolute spleen lymphocyte depletion. However, there was an enrichment of spleen T cells necessary to cause a graft-versus-host reaction (GVHR) in (C3H x BALB/c) F1 neonates. The effect was present 6 days after
PCB
administration and was no longer present on days 12-13. These studies suggest a transient effect of acutely administered PCBs on splenic lymphocytes (B cells, null cells, some T cells) other than mature
GVH
inducing T cells. The effect may be either similar to or possibly indirectly mediated by corticosteroids.
...
PMID:Acutely administered polychlorinated biphenyls (PCBs) decrease splenic cellularity but increase its ability to cause graft-versus-host reactions in BALB/c mice. 678 Apr 87
