Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018133 (
graft-versus-host disease
)
18,032
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Although hypereosinophilia (HE) associated with chronic
graft-versus-host disease
(
GVHD
) has long been recognized, biological data on this phenomenon are scarce. Here we compare patients with chronic
GVHD
with HE together with a clonal T cell expansion and control patients with acute or chronic
GVHD
but without HE. These clonal expansions share a CD8(+) TC1 phenotype rather than a CD4(+) Th2 profile. In contrast to the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, these allogeneic CD8(+) clones do not recognize the epitopes of herpesviruses. Furthermore, these TC1 clones do not produce IL-17 as described in the
DRESS syndrome
.
...
PMID:Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia. 2446 38
