Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018133 (graft-versus-host disease)
 18,032 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bronchoalveolar lavage (BAL) cytology and immunoglobulin components of lavage fluid were studied during non-bacterial/non-fungal interstitial pneumonitis, bacterial/fungal pneumonia, and Pneumocystis carinii infection. Lavages done before bone marrow transplantation and in asymptomatic phases were used as controls. The total cell recovery was increased during lung processes of any aetiology. Non-bacterial/non-fungal pneumonitis caused a significant increase in the number of lymphocytes; the number of neutrophils increased particularly during bacterial pneumonia. In Pneumocystis carinii pneumonia the typical cell picture was an increased percentage of lymphocytes together with blasts. During acute graft-versus-host disease without respiratory symptoms the cytology in lavage fluids did not differ from the controls. Cytomegalovirus (CMV) isolation was frequently positive in lavage fluids regardless of the presence or absence of pulmonary symptoms, but most of the symptom-free CMV-positive patients did not have any marked changes in BAL cytology. The albumin content of BAL fluid increased during infectious and immunological processes in lungs.
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PMID:Use of bronchoalveolar lavage cytology and determination of protein contents in pulmonary complications of bone marrow transplant recipients. 215 19

Recent years have witnessed a reduction in the frequency of infectious complications both in allogeneic and in autologous bone marrow transplantation (BMT). With a frequency of 30-40 percent, septicaemia is the predominant problem during the aplastic phase. Owing to the introduction of prophylaxis with quinolones, there has been a shift in the aetiological spectrum toward Gram-positive infections, and Gram-negative infections now account for less than 10 percent of all cases. In turn, this has been accompanied by reduced mortality. Early institution of treatment based on viraemia diagnosis has radically reduced the substantial morbidity and mortality formerly due to cytomegalovirus infection during the first three months after BMT. Antibiotic prophylactic treatment for Pneumocystis carinii infection during the first year, and against pneumococcal infections thereafter, has also been highly successful. The remaining problems are the diagnosis and treatment of invasive fungal infections and the increased susceptibility to infection among those who develop graft-versus-host disease.
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PMID:[Infections following bone marrow transplantation]. 852 35