Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
xanthine oxidase 380
Sep 326
ankylosing spondylitis 106
cytokine 98
insulin 89
NLRP3 88
Mol 81
ABCG2 75
IL-1 74
hypoxanthine-guanine phosphoribosyltransferase 72
chronic renal failure 70
TNF 56
MRI 55
ATP 50
RST 47
SLC2A9 45
C-reactive protein 44
uromodulin 43
IL-6 41
IL-8 38
IL-18 36
HPRT 35
xanthine oxidoreductase 32
collagen 32
tumor necrosis factor 32
SLC22A12 30
AII 30
pyrin 30
gut 30
MSU 27
GLUT9 26
NALP3 26
Mal 26
lipopolysaccharide 26
NOD 25
rheumatoid factor 25
albumin 25
HDL 24
She 24
hemoglobin 24
CRP 22
X-linked 22
NMR 21
proximal tubule 21
renin 20
TLR4 18
chemokine 17
THP 17
AMP 17
ATP-binding cassette 17
IL-10 16
COX-2 16
BCRP 16
hemochromatosis 16
urate transporter 1 15
HLA 15
ASC 14
hypoxanthine guanine phosphoribosyltransferase 14
cyclooxygenase-2 14
Pol 13
ACR 13
TOF 13
JAMA 13
catalase 13
PEG 13
Caspase-1 13
endoplasmic reticulum 13
LPS 12
glucose transporter 12
xanthine dehydrogenase 12
asymmetrical 12
Men 12
OAT1 12
cytochrome P450 12
NPT1 11
fibrinogen 11
alkaline phosphatase 11
IgA 11
anion exchanger 11
purine nucleoside phosphorylase 11
myeloperoxidase 11
interleukin-6 11
ROS 11
cyclooxygenase 10
CYP2C9 10
GFR 10
C18 10
Breast Cancer Resistance Protein 10
creatine kinase 10
parathyroid hormone 10
glycoprotein 9
IL-1 beta 9
IL-33 9
MTP 9
IL-17 9
PRPS1 9
aspartate aminotransferase 9
ACS 9
ESR 9
PDZK1 9
ATPase 9
ICD 8
OAT3 8
IFN 8
human leukocyte antigen 8
TLR2 8
ACE 8
Bcl-2 8
IMP 8
reductase 8
Tamm-Horsfall glycoprotein 8
HLA-B*5801 8
beta-endorphin 8
leptin 8
granulocyte 8
reserved 8
ALDH2 8
CD14 8
CXCL1 8
serum albumin 8
axonal 8
superoxide dismutase 8
CYP3A4 7
calcium channel 7
TNF-alpha 7
FJHN 7
HLA-B27 7
ADP 7
p65 7
ESI 7
P-glycoprotein 7
SOD 7
peroxidase 7
organic anion transporter 7
adrenocorticotropic hormone 7
glucose-6-phosphatase 7
apolipoprotein B 6
transporter 1 6
solute carrier 6
GCKR 6
tumor necrosis factor alpha 6
ALPK1 6
tyrosine kinase 6
ABC transporter 6
flavoprotein 6
SLC17A3 6
NLRC4 6
FRAP 6
interferon 6
nitric oxide synthase 6
collagenase 6
AIM2 6
CD4 6
CSF 6
matrix metalloproteinase 6
X-chromosome 6
lymphoid 6
S100A9 6
inducible nitric oxide synthase 6
GSH 6
more...
Disease
gout 5192
hyperuricemia 1159
arthritis 1107
hypertension 555
rheumatoid arthritis 529
diabetes 455
tophi 420
osteoarthritis 336
obesity 272
renal disease 268
arthropathy 188
metabolic syndrome 172
cardiovascular disease 163
cancer 160
pseudogout 150
systemic lupus erythematosus 145
renal failure 128
type 2 diabetes 122
ankylosing spondylitis 113
rheumatism 110
atherosclerosis 104
septic arthritis 104
renal insufficiency 103
chondrocalcinosis 102
psoriatic arthritis 87
chronic renal failure 87
hyperlipidemia 83
tumor 83
renal impairment 77
synovitis 76
heart failure 75
psoriasis 74
urolithiasis 70
stroke 64
nephrolithiasis 64
Gouty arthritis 63
polyarthritis 62
acute arthritis 61
coronary heart disease 59
familial Mediterranean fever 58
Lesch-Nyhan syndrome 58
dyslipidemia 57
osteoporosis 54
tuberculosis 51
depression 50
metabolic disorder 50
myocardial infarction 50
asthma 50
coronary artery disease 46
hyperparathyroidism 46
tenosynovitis 45
sepsis 40
congestive heart failure 39
anemia 39
infectious diseases 39
lupus 39
sepsis 38
vasculitis 37
bursitis 37
proteinuria 37
fibromyalgia 36
carpal tunnel syndrome 35
Alzheimer's disease 34
nephritis 34
hepatitis 34
monoarthritis 33
podagra 33
chronic disease 33
Reiter's syndrome 32
lupus 32
myocardial ischemia 31
amyloidosis 31
osteomyelitis 30
multiple sclerosis 29
rash 28
alcoholism 28
hypercholesterolemia 27
maple syrup urine disease 27
acute renal failure 26
spondyloarthropathy 25
scleroderma 25
NOD 25
myopathy 25
heart disease 24
tendinitis 24
rheumatic fever 24
dehydration 23
pneumonia 23
cold 22
crystal arthropathy 22
hypothyroidism 22
tumor lysis syndrome 21
epilepsy 21
Best 21
vascular disease 20
periarthritis 20
HIV 20
gallstones 20
fatty liver 20
hemochromatosis 20
polymyalgia rheumatica 19
metastases 19
peptic ulcer 19
Behcet's disease 18
essential hypertension 18
liver disease 18
peritonitis 18
PSS 18
neuropathy 18
Crohn's disease 18
chronic obstructive pulmonary disease 18
pericarditis 17
cirrhosis 17
Parkinson's disease 17
sarcoidosis 17
interstitial nephritis 16
hyperlipoproteinemia 16
hypercalcemia 16
inflammatory joint disease 16
hyperostosis 16
glucose intolerance 16
eosinophilia 16
calcinosis 16
villonodular synovitis 16
confusion 15
chondromatosis 15
juvenile rheumatoid arthritis 15
sickle cell disease 15
Septic arthritis 14
multiple myeloma 14
uricosuria 14
ischemia 14
NPHP1 14
inflammatory bowel disease 14
infectious arthritis 14
cellulitis 14
leukemia 14
pyelonephritis 13
pancreatitis 13
arteriosclerosis 13
immunodeficiency 13
gouty nephropathy 13
Mycobacterium 13
Acute gouty arthritis 13
malaria 13
virus infection 13
arthrodesis 13
hyperglycemia 12
chronic pain 12
Infection 12
polymyositis 12
PDB 12
osteochondromatosis 12
glomerulonephritis 12
acute myocardial infarction 12
melanoma 12
autoimmune disease 12
cataract 12
cardiovascular risk factor 12
enthesitis 11
more...
Symptom
pain 371
arthralgia 54
overweight 47
weakness 44
diarrhea 42
back pain 40
low back pain 28
erythema 27
headache 26
angina 23
vomiting 20
nausea 18
abdominal pain 17
knee pain 17
sciatica 16
fatigue 15
myalgia 15
neck pain 14
renal colic 13
polyuria 12
discomfort 12
hepatomegaly 12
acute pain 12
discomfort 12
numbness 12
anorexia 10
analgesia 10
dyspnea 10
cough 9
dizziness 9
seizures 9
collapse 9
constipation 8
dysuria 8
anesthesia 8
hemiplegia 7
colic 7
swollen joints 6
ataxia 6
neuralgia 6
flank pain 6
hip pain 6
splenomegaly 6
wrist pain 6
lethargy 6
tremor 6
acidity 5
oliguria 5
hypotonia 5
ankle pain 5
chills 5
spasticity 5
paresthesia 5
shoulder pain 5
flushing 5
stigma 4
thinning 4
shortness of breath 4
heel pain 4
sleepiness 4
dystonia 4
starvation 4
paresis 4
dental pain 4
Wind 4
heartburn 3
hepatosplenomegaly 3
elbow pain 3
hoarseness 3
vertigo 3
hemoptysis 3
dry eye 3
night sweats 3
paraparesis 3
chronic back pain 3
functional recovery 3
dysesthesia 3
dysarthria 3
decreased appetite 3
Ill 3
respiratory distress 3
fever of unknown origin 3
asthenia 3
insomnia 2
hypoproteinemia 2
masculinization 2
ACHE 2
leg pain 2
distraction 2
abdominal discomfort 2
prostration 2
agitation 2
groin pain 2
stomach pain 2
adenitis 2
exhaustion 2
arm pain 2
bone pain 2
toe pain 2
nausea and vomiting 2
leg cramps 2
emaciation 2
enuresis 2
facial pain 2
muscle cramps 2
pelvic pain 2
metatarsalgia 2
epigastric pain 2
loin pain 2
Foot pain 2
sore throat 1
generalized rash 1
thigh pain 1
chest tightness 1
athetosis 1
hypercapnia 1
vaginal itching 1
hyperemesis gravidarum 1
hypothermia 1
finger pain 1
forgetfulness 1
urinary frequency 1
acute abdominal pain 1
livedo 1
thirsty 1
Tenderness 1
limb pain 1
wheezing 1
cachexia 1
ENT 1
ischuria 1
acute abdomen 1
cerebellar ataxia 1
cancer pain 1
abdominal cramps 1
polydipsia 1
catarrh 1
chest pain 1
pleuritic chest pain 1
cardiovascular impairment 1
Sudden deafness 1
snoring 1
Decreased activity 1
spasm 1
pallor 1
cyanosis 1
Soft stools 1
musculoskeletal disability 1
Stiffness 1
despair 1
exertional dyspnea 1
localized edema 1
consciousness disturbance 1
polymyalgia 1
bitter taste 1
stridor 1
mental fatigue 1
abnormal gait 1
Anoxia 1
memory loss 1
more...
Drug
Febuxostat 74
Dermatol 45
Rasburicase 31
ascorbate 20
Nephron 18
Nephron 18
Cardiovasc 17
caffeine 12
ROS 11
Anakinra 10
IL-1ra 10
lysine 9
Dial 9
Rasburicase 8
Fructose 8
Indomethacin 7
CSF 7
vitamin E 4
niacin 4
Leaf 4
Monit 4
Rilonacept 4
TMX 3
G-CSF 3
ABC 3
lactose 3
ENT 3
Bifidobacterium 3
IL-2 3
PTH 2
Myricetin 2
Adenosine triphosphate 2
citric acid 2
Fenoprofen 2
Etodolac 2
Tenoxicam 2
Avonex 2
Y-700 2
Ethanol 2
Bumetanide 2
ampicillin 2
Albumin 2
Orphan 2
ADR 2
IFN-gamma 2
Spectrum 2
Tocilizumab 2
Copaxone 2
Activin 2
Itraconazole 2
Glutathione 2
Acemetacin 2
Potassium citrate 2
nitroglycerin 2
Meclomen 1
Meclomen 1
MRC 1
Aztec 1
Hydrochlorothiazide 1
Felodipine 1
Bayer 1
Compound 19 1
Rutin 1
balanced salt solution 1
Digitalis 1
Sucralfate 1
NBT 1
Immucillin-G 1
Nimesulide 1
CIA 1
CDP 1
Fluorescein 1
EPI 1
Voltaren 1
C18H16N4 1
Piretanide 1
Diclofenac sodium 1
Pirprofen 1
Riboflavin 1
ddI 1
FLP 1
AZT 1
ROC 1
ADM 1
NAG 1
FAD 1
Glatiramer Acetate 1
AGG 1
Adenosine Monophosphate 1
Aliskiren 1
Polycillin-PRB 1
Rosuvastatin 1
Indoprofen 1
Guanethidine 1
Simvastatin 1
CTT 1
Flunixin 1
CTX 1
NADH 1
Lovastatin 1
Methylene blue 1
Fenbufen 1
Posture 1
Feprazone 1
Clofibrate 1
Coumadin 1
ACT 1
Adenosine deaminase 1
Reserpine 1
Misoprostol 1
Imatinib 1
Angiotensin II 1
Isoniazid 1
Ranitidine 1
p75 1
Orlistat 1
Ketotifen 1
Silica 1
Papain 1
Fraction 1
Tranilast 1
Cilostazol 1
Camp 1
Feldene 1
AZT 1
Troglitazone 1
Lemon oil 1
Aloe 1
Forskolin 1
Ketoconazole 1
Asthma 1
Bendrofluazide 1
Mifobate 1
Enzyme
xanthine oxidase 361
uricase 132
caspase-1 65
hypoxanthine-guanine phosphoribosyltransferase 56
xanthine dehydrogenase 35
PRPP synthetase 28
renin 20
peroxidase 17
catalase 14
mitogen-activated protein kinase 13
creatine kinase 13
adenine phosphoribosyltransferase 12
aspartate aminotransferase 12
alanine aminotransferase 12
ERK 12
alkaline phosphatase 11
ACE 11
superoxide dismutase 11
aldehyde dehydrogenase 9
purine nucleoside phosphorylase 9
ATPase 9
ACS 9
focal adhesion kinase 7
CYP3A4 7
glucose-6-phosphatase 7
NADPH oxidase 7
lactate dehydrogenase 7
guanase 7
elastase 7
calcineurin 7
NADPH oxidase 7
aldehyde dehydrogenase 7
P-glycoprotein 7
proteasome 6
collagenase 6
aldehyde dehydrogenase 5
reverse transcriptase 5
glutathione peroxidase 5
aldehyde dehydrogenase 5
aldehyde dehydrogenase 5
neutrophil elastase 5
gamma-glutamyl transpeptidase 5
glutathione reductase 5
DNase 5
beta-glucuronidase 5
cathepsin B 5
adenosine deaminase 5
protein kinase C 4
lipoxygenase 4
ornithine aminotransferase 4
trypsin 4
caspase-3 4
aldehyde oxidase 4
thromboplastin 4
adenosine deaminase 4
urease 4
phospholipase A2 4
RNase 3
RNase 3
NO synthase 3
acid phosphatase 3
adenylate cyclase 3
urease 3
IKK 3
AMP deaminase 3
urokinase-type plasminogen activator 3
prostaglandin synthetase 3
lipoprotein lipase 3
orotidine-5'-phosphate decarboxylase 2
allantoicase 2
lysozyme 2
allantoinase 2
adenylosuccinate lyase 2
AMP-activated protein kinase 2
amidophosphoribosyltransferase 2
caspase-11 2
arginase 2
orotate phosphoribosyltransferase 2
Hageman factor 2
5'-nucleotidase 2
protein phosphatase 2A 2
phosphatidylinositol 3-kinase 2
asparaginase 2
monoamine oxidase 2
GSK 2
AST 2
protein kinase 2
phosphorylase 2
caspase-11 2
adenosine kinase 2
lipase 2
glyceraldehyde-3-phosphate dehydrogenase 2
MIP 2
adenine deaminase 2
papain 2
ALDH 2
cathepsin K 2
glutamate dehydrogenase 1
17beta-HSD 1
phospholipase C 1
5'-methylthioadenosine nucleosidase 1
glutaminase 1
PDK1 1
phospholipase D 1
MMP 1
phosphofructokinase 1
glutamate dehydrogenase 1
cathepsin G 1
tyrosinase 1
sulfite oxidase 1
peptidylarginine deiminase 1
ureidoglycolate hydrolase 1
lactic acid dehydrogenase 1
diamine oxidase 1
glyceraldehyde-3-phosphate dehydrogenase 1
sulfite oxidase 1
lysin 1
phosphoenolpyruvate carboxykinase 1
acetylcholinesterase 1
phosphoenolpyruvate carboxykinase 1
methylenetetrahydrofolate reductase 1
carbonic anhydrase 1
N-acetyltransferase 1
hexosaminidase 1
thyroid peroxidase 1
complex I 1
transglutaminase 1
kallikrein 1
glyceraldehyde-3-phosphate dehydrogenase 1
NQO1 1
ureidoglycolate lyase 1
methylmalonyl-CoA mutase 1
thymidylate synthase 1
caspase-4 1
choline oxidase 1
dihydroorotate dehydrogenase 1
p100 1
HSD 1
glyceraldehyde-3-phosphate dehydrogenase 1
caspase-5 1
alpha-mannosidase 1
MEK 1
GMP reductase 1
lactic acid dehydrogenase 1
STR 1
HK2 1
dihydroorotate dehydrogenase 1
thrombin 1
glucose oxidase 1
lecithin:cholesterol acyltransferase 1
cytochrome oxidase 1
tryptase 1
caspase-9 1
paraoxonase 1
MDR 1
mu-calpain 1
IMP dehydrogenase 1
proteinase K 1
Pla 1
topoisomerase 1
more...
Compound
Clin 638
Dec 359
calcium 265
Uric acid 206
creatinine 187
HPP 155
Colchicine 140
sodium 112
glucose 111
potassium 95
oxygen 88
water 87
DNA 69
phosphate 68
TNF 56
His 55
ethanol 55
ATP 50
urea 45
nitrogen 36
hydrogen 35
salt 32
acetate 31
Probenecid 27
pyrimidine 26
pyrimidine 26
PEG 26
nitric oxide 25
oxalate 24
Benzbromarone 24
iron 24
EDTA 21
methanol 21
EDTA 21
Cardiol 19
ammonium 19
molybdenum 18
THP 17
Purine 17
THP 17
PEG 16
arginine 16
cysteine 15
DPPH 15
ethyl acetate 15
Pac 14
ASC 14
tyrosine 13
galactose 13
leucine 13
TOF 13
acetonitrile 13
iodine 12
copper 12
GMP 12
caffeine 12
lysine 12
serine 11
vitamin D 11
acetic acid 11
Oxypurinol 11
H2O2 11
Dial 10
IMP 10
phosphorus 10
zinc 9
ACS 9
ACS 9
Phe 9
Xanthine 9
Optimal 9
Asp 9
alanine 8
formic acid 8
kaempferol 8
formic acid 8
formic acid 8
GSH 8
ammonia 8
Fructose 8
chloroform 8
formic acid 8
formic acid 8
formic acid 8
hexane 8
ADP 8
Thiazide 8
formic acid 8
aluminum 8
formic acid 8
GSH 8
ADP 8
Cholesterol 8
formic acid 8
formic acid 8
Insulin 7
hydroxide 7
aspartic acid 7
ADP 7
PRPP 7
AMP 7
PGE 7
Indomethacin 7
sulfate 7
Diclofenac 7
carbonate 7
propionic acid 6
tryptophan 6
ASA 6
cAMP 6
tryptophan 6
aldehyde 6
aspartic acid 6
Pyrazinamide 6
aldosterone 6
APAP 6
propionic acid 6
acrylamide 6
Hypoxanthine 6
aspartic acid 6
NAD 6
myricetin 6
tryptophan 6
Ile 6
gallic acid 6
aspartic acid 6
BMC 6
ACTH 6
Etoricoxib 6
tryptophan 6
isoleucine 5
aldehyde 5
Cyclosporine 5
PGE2 5
Lead 5
HCl 5
Tienilic acid 5
Diabetol 5
nitrate 5
Naproxen 5
glutamic acid 5
glutamine 5
T10 5
uridine 5
isoleucine 5
retinol 5
A 71 5
glutamate 5
Quercetin 5
phenol 4
Mg2+ 4
Phenylbutazone 4
TCM 4
hexose 4
hexose 4
PMA 4
GTP 4
sodium chloride 4
Caffeic acid 4
PMA 4
more...