Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied 25 patients with crystal-proven gout or roentgenographic evidence of gouty arthritis, or both, in finger joints involved with nodal osteoarthritis (OA). These patients were elderly (mean age 71.4 years), and 72% of them were receiving diuretic therapy. Roentgenographic findings, in addition to features typical of OA, included soft tissue densities (tophi), with or without calcification, large intraarticular erosions, characteristic nonmarginal cortical erosions, and periarticular osteolysis. We conclude that urate crystals mediate episodes of acute inflammation in certain patients with nodal OA. This association is noted primarily in elderly patients of both sexes, especially in those receiving diuretic therapy.
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PMID:Urate-mediated inflammation in nodal osteoarthritis: clinical and roentgenographic correlations. 278 53

A 63-year-old man developed generalized lymphadenopathy with skin rashes, fever, hepatomegaly and polyclonal hypergammaglobulinemia, twice, in February 1972 and in June 1979, after taking allopurinol for gout. Cervical lymph node biopsy, performed each time, showed the presence of immunoblasts and plasma cells, effaced nodal structure with involvement of the pericapsular tissue, rich vascularity and numerous mitoses, indicative of angio-immunoblastic lymphadenopathy with dysproteinemia (Frizzera, Moran and Rappaport). The existence of hypersensitivity to drugs, in particular, allopurinol in certain patients was emphasized, and induction of immunoblastic lymphadenopathy with various other therapeutic agents was briefly discussed.
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PMID:A case of angio-immunoblastic lymphadenopathy with dysproteinemia related to allopurinol. 645 13

Recently gout has been recognized as a cause of inflammation in patients with nodal osteoarthritis. We reviewed the clinical data and radiographs of four patients with known osteoarthritis of the interphalangeal joints of the hands who developed gout. Radiographic changes of osteoarthritis in the affected interphalangeal joint were present in all four patients. In our cases, radiographic findings were typical of gout in one patient, including the presence of large eccentric soft tissue masses and periarticular erosions. In three patients, radiographic findings were non-specific, including only a small eccentric nodule in one patient, diffuse soft tissue swelling in a second, and a large calcified soft tissue mass with bony erosions in a third. Whenever a patient with inter-phalangeal joint osteoarthritis presents with an acute episode of inflammation the possibility of gout should be considered. Recognition of gout will allow the timely initiation of appropriate therapy.
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PMID:Nodal osteoarthritis and gout: a report of four new cases. 883 72