Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018099 (
gout
)
5,192
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Although astroviruses causes enteric diseases and encephalitis in humans and nephritis and hepatitis in poultry, astrovirus infection is thought to be self-limiting. However, little is known about its molecular mechanism. In this study, we found that a novel goose astrovirus (GAstV), GAstV-GD, and its open reading frame 2 (ORF2) could efficiently activate the innate immune response and induce a high level of
OASL
in vitro
and
in vivo
The truncation assay for ORF2 further revealed that the P2 domain of ORF2 contributed to stimulating
OASL
, whereas the acidic C terminus of ORF2 attenuated such activation. Moreover, the overexpression and knockdown of
OASL
could efficiently restrict and promote the viral replication of GAstV-GD, respectively. Our data not only give novel insights for elucidating self-limiting infection by astrovirus but also provide virus and host targets for fighting against astroviruses.
IMPORTANCE
Astroviruses cause gastroenteritis and encephalitis in human, and nephritis, hepatitis, and
gout
disease in poultry. However, the host immune response activated by astrovirus is mostly unknown. Here, we found that a novel goose astrovirus, GAstV-GD, and its ORF2 protein could efficiently induce a high level of
OASL
in vitro
and
in vivo,
which could feed back to restrict the replication of GAstV-GD, revealing novel innate molecules triggered by astroviruses and highlighting that the ORF2 of GAstV-GD and
OASL
can be potential antiviral targets for astroviruses.
...
PMID:OASL Triggered by Novel Goose Astrovirus via ORF2 Restricts Its Replication. 3296 52
