Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with factor XII deficiency, gout, and angioimmunoblastic lymphadenopathy (AIL) was seen initially for an acute myocardial infarction, gout, and unexplained urticaria. The patient eventually was found to have AIL and a prolonged partial thromboplastin time. There was no evidence of a circulating anticoagulant. A factor XII deficiency (Hageman factor) was discovered. The coexistence of a factor XII deficiency, AIL, and gout in the same person raises some interesting questions regarding the basic mechanisms of the inflammatory process.
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PMID:Factor XII deficiency in a man with gout and angioimmunoblastic lymphadenopathy. 673 12

A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.
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PMID:Classic gout in Hageman factor (Factor XII) deficiency. 710 39