Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In humans, there is a negative correlation between gout and rheumatoid arthritis. Similarly, rats rendered hyperuricemic by an oxonate diet appeared resistant to develop adjuvant arthritis. These animals exhibited a normal inflammatory response to a subplantar injection of carrageenin and normal humoral and cell-mediated immune responses to a sensitizing dose of EL4 cells. However, unlike that of normal animals, the cell-mediated immune system of the oxonate-treated rats was found to be unable to respond to adjuvant stimulation, which may be the basis for their resistance to develop adjuvant disease.
J Pharmacol Exp Ther 1981 Dec
PMID:Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of acute inflammation, immune response and adjuvant arthritis. 697 69

Intraosseous calcification in association with gouty arthritis was observed in six patients and a single cadaver. This finding, which is usually associated with chronic tophaceous gout, extensive articular destruction, and severe renal disease, is usually seen in the hands, wrists, and feet. It may be associated with additional calcific deposits in the adjacent soft tissues. Although the radiographic appearance of the calcification simulates that of an enchondroma or bone infarct, the abnormality seems related to intraosseous penetration of calcified urate deposits.
AJR Am J Roentgenol 1981 Dec
PMID:Intraosseous calcifications in tophaceous gout. 697 85

In the pathogenesis of painful dysfunctions of the locomotor apparatus superficial pain, deep pain and compression pain as well as referred pain play a role. The development of this pain is discussed. The differential diagnosis of radicular and pseudoradicular forms of pain of the vertebral column is discussed. The most clinical important rheumatic pain syndromes, myalgia, arthritis and arthrosis as well as the development of pain in gout attacks are described according to the natural history and clinical presentation of the disease. Therapeutic indications are given. The importance of the differential diagnostic evaluation of pain syndrome is stressed, in particular if it seems, that there is no organic background.
Wien Med Wochenschr 1982 Dec 31
PMID:[Pathogenesis and clinical features of painful dysfunctions of the locomotor system]. 698 65

Practically 10-20% of all patients registered with a General Practitioner complains of symptoms in some way associated with rheumatism. Incidences of this disorder are distributed in such a way as to form a pattern whereby 55% is troubled with extra-articulary rheumatism, 38% with arthrosis and spondylarthrosis and 7% with rheumatoid arthritis. It is of most importance that the General Practitioner identifies these patients during the early stages of their disorder, and that he commerces the necessary treatment immediately. With the exception of streptococcus-rheumatism and gout, the pathogenesis of rheumatics eludes us to this day. As far as individual measures are concerned therefore, it is merely a question of selecting some kind of treatment, ranging from the symptomatic to the semi-causal, which can be used alongside the recommended form of therapy. The author describes various kinds of treatment including NSTAR, Glucocorticoids, Antisuppressives and basic therapy such as Chloroquin, gold and D-Penicillamin.
Wien Med Wochenschr 1982 Dec 31
PMID:[Comprehensive review of the possibilities and limits of drug therapy of rheumatic diseases]. 698 70

With the exception of the treatment of gout and bacterial infections of joints, therapy in the rheumatic diseases remains inadequate. Although many patients gain symptomatic improvement on the drugs currently available, their impact on the underlying disease process remains uncertain. Hope for future therapeutic development is highest in rheumatoid arthritis with the second-line agents (e.g. gold, penicillamine), as unravelling their mechanism of action may lead to the design of more effective and less toxic medications. The cytotoxic agents appear to hold some promise in the therapy of vasculitis, but problems with their use have by no means been solved. In the major problem area of osteoarthritis, important gains are being made in the field of joint replacement, and the use of non-steroidal anti-inflammatory drugs in the interim has made symptoms more tolerable. Obviously much remains to be done in research in the area of antirheumatic drugs.
Drugs 1980 Dec
PMID:Antirheumatic drugs: clinical pharmacology and therapeutic use. 700 34

Consumption of alcoholic beverages is associated with hyperuricemia and gout. To determine the contributions to this process of increased production and decreased excretion of uric acid, we gave oral ethanol (1.8 g per kilogram of body weight every 24 hours) for eight days or intravenous ethanol (0.25 to 0.35 g per kilogram per hour) for two hours to six patients with gout. During the long-term oral study we observed the following: serum urate levels increased from 8.4 +/- 0.4 (mean +/- S.E.) to 10.1 +/- 0.9 mg per deciliter; whole blood lactate reached a peak of 3.1 +/- 0.7 mM from a base line of 1.3 +/- 0.3 mM; and urinary oxypurines increased to 641 +/- 397 per cent of the base-line value. Urate clearance increased to 145 +/- 25 per cent of the base-line value. Daily uric acid turnover increased from 1010 mg per deciliter to 170 +/- 17 per cent of the base-line value. During short-term intravenous ethanol administration, serum urate levels, urate clearance, and urinary uric acid excretion were not substantially altered from the base-line period. Urinary oxypurine levels increased to 341 to 415 per cent of base-line values. Urinary radioactivity, originating from the adenine nucleotide pool labeled by [8-(14)C]adenine, increased to 127 to 149 per cent of base-line values. These data indicate that ethanol increases urate synthesis by enhancing the turnover of adenine nucleotides.
N Engl J Med 1982 Dec 23
PMID:Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover. 714 47

Of 264 patients with urolithiasis those with pure uric acid or urate stones were compared to those with other types of calculi for differences in epidemiologic factors and uric acid, calcium and phosphate metabolism. Patients with uric acid stones were predominantly older men. These patients had comparatively lower incomes and spent less money on food but consumed more alcohol. The urinary pH was lower than in the other groups. The absence of abnormally elevated serum uric acid levels and elevated 24-hour urinary uric acid excretion suggests this variety of uric acid lithiasis to be idiopathic in nature. This finding is supported by the results of standardized oral purine loading, which showed no post-loading differences in serum levels and revealed urinary concentrations in 12 patients with pure uric acid stones and 10 normal subjects. However, there is evidence to suggest that this condition may be a precursor of primary gout. Hereditary mechanisms are absent and the relapse rate is the same as in patients with other stones. Therefore, our results suggest the existence of an idiopathic variety of uric acid lithiasis that, at least in central Europe, occurs more frequently than previously assumed. The condition is not inherited, alcohol consumption is a major etiologic factor and there is no evidence of a causative role of abnormalities in purine metabolism.
J Urol 1982 Dec
PMID:Idiopathic uric acid lithiasis: epidemiologic and metabolic aspects. 715 74

The commonest causes of ulnar nerve compression in the epitrochlear groove have been widely reported in the literature. The author reports four rare causes, viz.: neurinoma of the ulnar nerve (one case), compression of the ulnar nerve due to an arthrogenic ganglion (two cases), ulnar neuritis due to articular gout (two cases), and compression of the ulnar nerve due to post-traumatic fibrosis in the epitrochlear groove (one case).
Ital J Orthop Traumatol 1980 Dec
PMID:Rare causes of ulnar nerve compression in the epitrochlear groove. 721 40

The following assertion - continuously being alleged - is examined: Hallux rigidus arthrosis is said to occur in patients suffering from gout more frequently than average, and it should be valued as a symptom of chronic gout. Results of our own findings are as follows: 1. Hallux rigidus arthrosis becomes manifest in general on the right side or bilaterally, respectively; on the left side, however, it occurs rarely in an isolated state. 2. In patients with hallux rigidus arthrosis hyperuricaemia, gout, and obesity are seen more frequently than in adults of the normal population - these three diseases often are combined with static mutations in the region of the lower extremities. 3. No criteria can be stated as to causal relationship between hyperuricaemia (or gout) and hallux rigidus arthrosis. Obesity has to be considered a connecting link between both of them, and it is accelerating their genesis. 4. Hallux rigidus arthrosis represents - same as the arthrosis of Heberden - the more frequent possibility for confusing it with gout.
Med Klin 1981 Dec 18
PMID:[Between hallux rigidus arthrosis and gout is no causal relationship]. 732 6

Salt poisoning developed in captive sandhill cranes (Grus canadensis) when sea salt was added to normal drinking water to produce a sodium chloride concentration of 1%. Two of 18 cranes died and 2 were euthanatized when moribund. Muscle weakness, paresis, dyspnea, and depression were observed. Brain and serum sodium, serum uric acid, and plasma osmolality values were abnormally high. Lesions were those of visceral gout, renal tubular necrosis, nephrosis, and skeletal muscle necrosis.
J Am Vet Med Assoc 1981 Dec 01
PMID:Iatrogenic salt poisoning in captive sandhill cranes. 732 5


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