Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nonarticular causes of elbow pain include muscle strains, ligamentous injuries, epicondylitis, olecranon bursitis, and compressive neuropathies. Overuse and trauma commonly cause these conditions. The history and physical examination differentiate them from an intra-articular process such as synovitis. Laboratory analysis of fluid aspirated from a swollen olecranon bursa is necessary to differentiate infection or gout. X-rays are useful in avulsion fracture, osteochondritis dissecans, and epiphyseal separation. Electromyography with nerve conduction velocities can localize the site of nerve entrapment. Treatment, in general, consists of prevention from further overuse, protection by rest and splinting to allow healing, pharmacologic intervention to reduce inflammation, relieve pain and combat infection, and physical therapy to restore motion and function. Surgery may be necessary to repair torn muscle, to release the wrist extensors in refractory lateral epicondylitis, and to decompress an entrapped nerve.
Prim Care 1988 Dec
PMID:Elbow pain. 306 91

A patient with amyloidosis secondary to polyarticular gout is presented in whom amyloid protein A (AA) was demonstrated in the kidney with a monoclonal antibody against protein A. The rarity of this association is discussed and a pathogenetic mechanism proposed.
Clin Rheumatol 1988 Dec
PMID:Amyloidosis secondary to gout. Identification with a monoclonal antibody to amyloid protein A. 307 36

Nineteen Myrtaceae collections belonging to 15 species, 12 of which are used in Paraguayan folk medicine, were assayed for inhibitory activity towards the enzyme xanthine oxidase. Most leaf and stem extracts were active showing IC50 values ranging from 3.0 to 50 micrograms/ml. The reported activities support existing ethnobotanical data concerning their use for the treatment of gout.
J Ethnopharmacol 1988 Dec
PMID:Xanthine oxidase inhibitory activity of Paraguayan Myrtaceae. 325 88

We recently conducted a cross-sectional survey of the prescribing practices of rheumatologists and a random sample of family physicians. While in general there was agreement as to the preferred management of gout, family physicians were (a) more likely to use phenylbutazone, (b) more liberal in their use of allopurinol, (c) less likely to cover the introduction of allopurinol with antiinflammatory agents or to titrate the dose against the serum uric acid, or to adjust the dose according to the serum creatinine. A small number of physicians continued to routinely use urate lowering drugs in the treatment of entirely asymptomatic hyperuricemia.
J Rheumatol 1988 Dec
PMID:A survey of current prescribing practices of antiinflammatory and urate lowering drugs in gouty arthritis in the province of Ontario. 818 60

Patients with rheumatic complaints are the subject of some 10% of the general practitioner's work. Approximately half of this work is related to the hitherto relatively neglected group of varied soft-tissue conditions, most of which are self-limiting and of a minor nature. Against a background of such diagnostic 'noise', the general practitioner has to remain alert for the fainter 'signal' of serious disease--rheumatic and non-rheumatic--at an early stage. Continuity of care calls on special qualities, behaviours and abilities in the doctor to boost and maintain morale, to coordinate management and to participate in team care. In addition to more traditional therapeutic measures, including analgesics, NSAIDs, disease-modifying drugs and physiotherapy, joint replacement is seen as a significant contribution. There is room for improvement in the structure process and outcomes of delivery of care as it may relate to rheumatic diseases. A simple illustration, based on a general practice audit of gout, is suggested as a possible model by which quality of care could be enhanced at the level of individual patients. While there is not a great deal of scope afforded to the general practitioner in the exercise of primary prevention of the rheumatic diseases, early diagnosis and timely support for carers of patients suffering from chronic rheumatic diseases are areas worth attention. Promotion of self-help is seen as a worthwhile activity in humanitarian and economic terms, though it calls for an appropriate balance to be struck.
Baillieres Clin Rheumatol 1987 Dec
PMID:Rheumatic diseases: a general practitioner's view. 333 35

For the dietary treatment of hyperuricemia and gout, it is necessary to know the total purine content of food. A new method determining the purine content enzymatically, as uric acid, allows routine analysis. Many foods of animal and plant origin were brought in usual or alternative stores and analysed.
Z Ernahrungswiss 1987 Dec
PMID:[Total purine content in selected foods]. 343 21

Numerous musculoskeletal and collagen diseases can affect the cervical spine and TMJs as well as other joints in the body, resulting in pain and dysfunction. A rational approach has been presented to aid in the differential diagnosis of these disorders when they involve the TMJs. When systemic inflammatory diseases such as gout, psoriatic arthritis, and rheumatoid arthritis are suspected, the patient should be seen jointly with a rheumatologist to better manage medication and rehabilitation of the patient. Although rheumatologic diseases may appear complex, they can be differentiated and managed with minimal difficulty for the dentist. Early relief of acute pain and long-term successful management, however, will depend on the clinician's ability to understand the disease process, establish an accurate diagnosis, and apply the proper therapeutic measures.
J Prosthet Dent 1986 Dec
PMID:A rational approach to the differential diagnosis of arthritic disorders. 346 54

Twenty-nine patients presenting to their general practitioners with acute gout were treated with tenoxicam 40 mg daily for two days then 20 mg daily for five days. The treatment was well tolerated and 79% of participants responded to therapy. Side affects were minor with no patients withdrawing from the treatment course.
N Z Med J 1987 Dec 09
PMID:An open assessment of tenoxicam (Tilcotil) in the treatment of acute gout in general practice. 350 45

Pirprofen is a non-steroidal anti-inflammatory drug, related structurally to drugs such as ibuprofen, ketoprofen and naproxen. Published clinical trials indicate that pirprofen 600 to 1200 mg/day as 2 or 3 divided doses is a suitable alternative to usual therapeutic dosages of aspirin, flurbiprofen, ibuprofen, indomethacin, ketoprofen, naproxen, piroxicam and sulindac in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, musculoskeletal disorders and non-articular rheumatism. More studies are required to evaluate its potential relative to other commonly used drugs in the treatment of gout, juvenile rheumatoid arthritis and dysmenorrhoea. In patients with acute postsurgical, trauma or cancer pain, single oral or intramuscular doses of pirprofen 200 to 400mg provide equivalent analgesic activity to usual therapeutic doses of aspirin, diflunisal, ketoprofen, noramidopyrine, paracetamol and pentazocine. As with other non-steroidal anti-inflammatory drugs, gastrointestinal complaints are the most frequently reported side effects. At equivalent analgesic or anti-inflammatory dosages, pirprofen probably causes fewer side effects than aspirin and appears to be as well tolerated as the other agents with which it has been compared. Long term tolerability, particularly compared with some of the newer, purportedly less gastrotoxic agents or formulations, needs to be investigated further. Pirprofen does not appear likely to offer any particular advantage with respect to efficacy and tolerability over other non-steroidal anti-inflammatory drugs, except aspirin. However, as no one agent is the most suitable drug for all patients requiring such therapy, pirprofen may be considered along with other drugs of this type in the therapy of arthritic conditions and acute pain states.
Drugs 1986 Dec
PMID:Pirprofen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. 353 73

Review of data in very old charts sometimes brings new insights and perspectives, and suggests new hypothesis for illnesses of patients long deceased. Such applications can be made if enough information is available, e.g., autobiographical letters, skeletal remains, pictorial representations. Finally the process must be discussed in the context of the major disease processes occurring at that time. When such an approach was applied to Erasmus (Rotterdam c 1466--Basle 1536), the differential diagnosis included gout, syphilitic arthritis and enteric rheumatism.
J Rheumatol 1986 Dec
PMID:Can a diagnosis be made in retrospect? The case of Desiderius Erasmus. 355 75


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>