Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018099 (
gout
)
5,192
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Visceral urate deposition (visceral
gout
) is a common finding during post-mortem examination of poultry. Rare cases of visceral
gout
may occur in wild birds. A rare case of visceral urate deposition in a little bittern (Ixobrychus minutus) is reported here. In May 2013, carcass of a little bittern was submitted for necropsy to the Clinic of Poultry Diseases (Faculty of Veterinary Medicine, Razi University) by local authorities of Iran Department of Environment. At necropsy, white chalky deposits were observed on the heart and thoracic air sacs of the bird. To confirm the presence of urates, chalky deposits were collected from pericardium and tested by muerxide test. Heart and kidneys were sampled, preserved in 10% neutral-buffered formalin solution and submitted to laboratory for histopathology.
Murexide
test was positive for presence of uric acid in chalky deposits collected from pericardium. Light microscopy of affected organs confirmed the condition as visceral urate deposition. To the best of our knowledge, this is the first report on the occurrence of visceral urate deposition in a little bittern.
...
PMID:Visceral urate deposition in a little bittern (Ixobrychus minutus). 2626 16
Colchicinoids and their derivatives are of great importance in pharmaceutical applications, and colchicine is usually used as the first choice for the treatment of
gout
. To expand the structural diversities and clinical application of colchicinoids, many attempts have been established for the derivatives with better activity or less toxicity. Herein, in this paper, we report a direct microbial transformation of colchicine into 2-O-demethyl-colchicine (M1) and 3-O-demethl-colchicine (M2) by Streptomyces griseus ATCC 13273. It is noteworthy that when
DMF
was used as co-solvent, the yield of M1 and M2 could reach up to 51 and 31%, respectively. All the structures of the metabolites were elucidated unambiguously by ESI-MS,
1
H-NMR,
13
C-NMR, and 2D-NMR spectroscopy.
...
PMID:Microbial Catalyzed Regio-Selective Demethylation of Colchicine by Streptomyces griseus ATCC 13273. 2845 4
