Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018099 (
gout
)
5,192
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Until the past decades, end stage renal disease was considered a major cause of death among patients with
gout
. Modern long-term follow up studies of renal function however have indicated that hyperuricemia and
gout
rarely result in kidney damage unless other renal diseases supervene. Subsequently, the use of the
EDTA
lead mobilization test confirmed that
gout
in the presence of chronic renal failure is a useful marker of chronic lead intoxication. Chelation treatment with
EDTA
can slow the progression of renal insufficiency, without apparent damage associated with the use of the chelating agent. Since chronic lead intoxication may remain clinically concealed for years, a high index of suspicion is warranted. Occult lead intoxication should be sought actively in gouty patients with chronic renal insufficiency of unknown etiology.
...
PMID:[Gout nephropathy--ghost or reality?]. 1549 17
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