Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients, 0.6%) and diarrhoea and drug fever (5 each, 0.3%). Adverse effects were dose-related. Reactions were unrelated to age, weight, reason for therapy, admission blood urea, or albumin concentrations. Acute exacerbation of gout was troublesome in 3 patients (1 in 600 exposed).
 ...
PMID:Acute adverse reactions attributed to allopurinol in hospitalised patients. 724 70

1. The age and sex distribution of the SUA of the Japanes people was the same as of the Caucasians. 2. The prevalence of gout was 0.4% of all the subjects, in adult male it was 1.2% and 76.4% in hyperuricemia above 10.0 mg/dl. 3. The incidence of a year throughout this population study was 0.02% per population. 4. Serum creatinine, body weight, height, age, urea-N, blood pressure and alcohol intake were strongly associated with SUA respectively. 5. Correlation analysis of SUA in familiar members showed the strong correlation between mother and son.
 ...
PMID:Hereditary and environmental factors influencing on the serum uric acid throughout ten years population study in Japan. 742 30

A report of 20 cases of gout considered to be secondary to chronic renal disease is presented. Studies of renal function and of uric acid metabolism were carried out in 16 patients. The daily production of urate remained within normal limits in the face of progressive renal dysfunction. Renal excretion of uric acid was decreased to a mean of 35.5% of the turnover. The cumulative urinary recovery of intravenously injected 14C-uric acid averaged 32.0%. In 3 patients 14C was successively retrieved in urinary allantoinand urea, in carbon dioxide of expired air, and in faeces. As in normal man, carbon dioxide and ammonia were the principal uricolytic products. The extrarenal excretion of uric acid assumes a greater role in chronic renal disease and eventually becomes the major route of elimination of uric acid. The possibility that gout may be secondary to intrinsic renal disease should be entertained when azotaemia is present.
 ...
PMID:Gout secondary to chronic renal disease: studies on urate metabolism. 743 73

The content of urea in a tear is close to that in the blood both in health and uremia. This fact permitted development of a new method of laboratory diagnosis of uremia from the content of urea in a tear. The method may be used to diagnose uremia in renal diseases and various endogenous poisonings with clinical manifestations of renal insufficiency. A method for the diagnosis of hyperuricemia from the content of uric acid in a tear has been developed. The method was used for the diagnosis of gout and hyperuricemia in renal diseases. The suggested methods are reliable and available for common clinical biochemical laboratories. Biochemical analysis of a tear is much simpler, rapid, and atraumatic than analysis of the blood collected from the vein.
 ...
PMID:[Diagnostic value of tear analysis in uremia, uricemia and cholesterolemia]. 789 98

The association between serum uric acid concentration and some cardiovascular risk factors was examined in a working Hong Kong Chinese population (mean age 38 years), consisting of 910 men and 603 women. There was no significant age-related rise in serum uric acid concentration. Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic and diastolic blood pressure, urea, creatinine, protein, glucose (fasting and 2 hours after 75 g oral glucose load), 2 hour insulin, triglycerides, and apolipoprotein B in men. Similar, but fewer, associations were seen in women, with the addition of a positive association with age. In both sexes, serum uric acid was negatively associated with high-density lipoprotein cholesterol. These findings complement the well-known clinical association between gout and cardiovascular and metabolic diseases, such as hypertension, hyperlipidaemia and diabetes mellitus, and suggest that serum uric acid may be a marker for the presence of an adverse cardiovascular risk factor profile.
 ...
PMID:Association between serum uric acid and some cardiovascular risk factors in a Chinese population. 793 26

A case is described in which, after administration of diclofenac for 13 days for arthritis attributed to gout, the patient experienced erythema multiforme followed by muscle weakness, elevation of serum creatine phosphokinase (CPK) level from 101 to 83,770 U/L, 100% muscle isoenzyme, blood urea nitrogen (BUN) level from 15 to 87 mg/dL, creatinine level from 1.0 to 2.1 mg/dL and urine myoglobin level to 1,190 micrograms/dL (N < 1.2). The diagnosis was rhabdomyolysis due to diclofenac, with myoglobinuria resulting in mild renal failure. Treatment consisted of discontinuing diclofenac and administering sufficient fluids to prevent progression of myoglobinuric renal failure. Serum CPK level gradually returned to normal by day 50, BUN and creatinine levels by day 28, and muscle strength between day 90 and 180. Rhabdomyolysis due to diclofenac or to other nonsteroidal antiinflammatory drugs has not been reported.
 ...
PMID:Case report: diclofenac-induced rhabdomyolysis. 870 74

A 59-year-old man with chronic obstructive pulmonary disease (COPD), atrial fibrillation, and gout developed acute dyspnea, cough, and diffuse muscle aches and pains. He had commenced colchicine (0.6 mg b.i.d. p.o.), for the first time, one month earlier for recurrent gout attacks. Clinical examination revealed atrial fibrillation, an exacerbation of his pulmonary disease, tender muscles, especially calves, and diffuse muscle weakness. Laboratory results included creatinine phosphokinase 6961 U/l (1% MB), microscopic hematuria, myoglobinuria, elevated creatinine 1.6 mg/dl, and blood urea nitrogen 17 mg/dl. COPD and atrial fibrillation were treated and colchicine was discontinued. The patient made a full recovery. This 2nd reported case of colchicine induced rhabdomyolysis is the first reported in the treatment of gout.
 ...
PMID:Colchicine induced rhabdomyolysis. 933 Sep 53

We identified 174 cases of chronic severe renal failure (blood creatinine > 650 mumol/l) and/or blood urea > 35 mmol/l) in a retrospective study of patients admitted to hospital between January 1989 and June 1996. Of these patients, 110 were men and 64 were women. The mean age was 36 +/- 15 years. Fifty three patients had a history of hypertension before admission, 3 patients had diabetes and 3 had gout. The most frequent clinical signs were dyspnea (55.2% of all patients), fatigue (78.2%), vomiting (63.2%) and edema (66.1%). The prevalence of hypertension was 64.9%. Glomerulonephritis was found in 42.5% of patients, chronic interstitial nephritis in 16.1%, polycystic kidney disease in 2 cases, congenital renal hypoplasia in 4 cases and unclassified kidney disease in 14.4% of cases. End-stage renal failure was complicated by heart failure in 40.2% of patients, pericarditis in 31.6%, hemorrhage of the gastrointestinal tract in 15% and infections in 22.4%. 47.7% of the patients died following admission.
 ...
PMID:[Epidemiology of severe chronic renal insufficiency in Burkina Faso]. 950 95

To determine the ability of cockatiels (Nymphicus hollandicus), a granivorous avian species, to adapt metabolically to high dietary protein levels, adult males (n = 26) were fed isocaloric diets containing 11, 20, 35 or 70% crude protein (CP) for 11 mo. Throughout the trial, body weight and breast muscle weight were maintained by 11, 20 or 70% CP. The 35% CP diet resulted in significantly greater body weight (P < 0.05) and whole-body lipid content (P < 0.05) compared with the 11% CP diet. The 20% CP diet resulted in greater breast muscle mass compared with 70% CP (P < 0.05). Activity of the amino acid catabolic enzymes alanine aminotransferase, aspartate aminotransferase and arginase as well as the gluconeogenic enzyme phosphoenolpyruvate carboxykinase were significantly increased with 70% CP (P < 0.05). Serum essential amino acids, urea and uric acid were also increased with 70% CP (P < 0.05), but the magnitude of their increase was similar to that found in omnivorous chickens fed a similar diet. There was no evidence of visceral gout, articular gout or renal pathology; however liver lesion severity, and specifically liver lipogranuloma severity, was significantly increased above 11% CP (P < 0.05). We conclude that cockatiels are able to up-regulate enzymes for amino acid catabolism as well as mechanisms for nitrogen excretion in response to high dietary protein levels, and that high dietary protein levels are not associated with kidney dysfunction in this avian species.
 ...
PMID:Adult cockatiels (Nymphicus hollandicus) metabolically adapt to high protein diets. 1143 23

CD27 is expressed on lymphocytes, but also on renal tubules. On the damaged renal tubules, CD27 is cleaved into soluble CD27 (sCD27) and cytoplasmic tail CD27. Renal tubule apoptosis is induced by the CD27 ligand, Siva, binding to the truncated tail CD27. Theoretically, serum sCD27 should be a marker of renal tubule apoptosis. Serum sCD27 levels were measured by ELISA in 274 patients at University Hospital School of Medicine, Japan. Among 73 males and 63 females with high plasma creatinine levels, 68 (93%) males and 51 (81%) females showed high serum sCD27 values (>or=500 U/ml). In the 42 males with plasma creatinine levels of 1.18-5.00 mg/dl and the 55 females with plasma creatinine levels of 0.83-4.65 mg/dl, the correlation coefficients between plasma creatinine and sCD27 were 0.605 and 0.469, respectively. SCD27 was a more sensitive marker of renal tubule apoptosis than plasma creatinine. Of 138 patients with normal plasma creatinine, 42 showed high serum sCD27 levels (>or=500 U/ml). Among the 42 patients, 19 patients had high blood urea nitrogen and 11 patients showed plasma creatinine elevations 3-11 days later. Nine patients with hemolysis and 39 patients with aneurysms had clearly higher sCD27 levels of 1633+/-483 U/ml and 905+/-437 U/ml, respectively, than normal values of 215+/-57 U/ml ( n=27) ( P value >or=0.001). Vasodilators, hypotensors, diuretics, and drugs for gout, arrhythmia, thrombosis, and diabetes were prescribed in 40%, 37%, 33%, 13%, 8%, 8%, and 5% of the 78 patients analyzed with high sCD27 levels (>or=500 U/ml). In total, 59 (76%) patients were prescribed at least one of the drugs. In conclusion, serum sCD27 was a more sensitive indicator of renal tubule apoptosis than plasma creatinine, especially during the early stage of apoptosis. Tubule apoptosis with high serum sCD27 levels was found in patients with glomerular vascular injuries.
 ...
PMID:High levels of serum soluble CD27 correlated with renal dysfunction. 1262 11


<< Previous 1 2 3 4 5 Next >>