Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have evaluated a simple dextran sulphate precipitation method for measuring high density lipoprotein cholesterol (HDL) subfractions and have used this method to measure plasma HDL2 and HDL3 in a group of 28 patients with primary gout. These patients were found to have significantly lower levels of plasma HDL and HDL2 than a group of healthy controls, matched for age and sex and of similar body mass index (BMI); no significant difference in mean levels of the HDL3 subfraction was found however. We have confirmed the high prevalence of hypertriglyceridaemia in subjects with gout compared to controls and the mean serum triglyceride levels were significantly higher (P less than 0.01) in the gout group than in controls. We have also shown that subjects with high serum triglyceride levels tend to have low plasma HDL2 concentrations, a finding which is consistent with an inverse relationship between these two parameters. These lipid abnormalities may partly explain the high prevalence of premature atherosclerosis in patients with primary gout.
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PMID:The measurement of high density lipoprotein subfractions in patients with primary gout using a simple precipitation method. 241 36

Using logistic regression analysis, we investigated whether or not excessive alcohol intake and increased BMI, both of which are known causes of lipid metabolism abnormality, are associated with increased serum triglyceride, apolipoprotein B concentrations and decreased high-density lipoprotein cholesterol (HDL-C), high-density lipoprotein 2 cholesterol (HDL2-C) levels in patients with gout. Serum triglyceride levels were significantly higher in patients with gout than in normal subjects. In contrast, serum levels of HDL-C and HDL2-C were significantly lower in patients with gout than in normal subjects. These results were further analysed using stepwise logistic regression. This analysis demonstrated that both serum triglyceride levels and alcohol consumption discriminated subjects with gout from controls but BMI, HDL-C and HDL2-C did not, suggesting that increased serum triglyceride levels exist intrinsically in gout, while decreased concentrations of HDL-C and HDL2-C may be attributed to hypertriglyceridaemia.
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PMID:Impaired lipoprotein metabolism in patients with primary gout--influence of alcohol intake and body weight. 805 99