Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The comparative acute, oral toxicity of ochratoxin A for three day-old avian species is presented. The seven-day LD50 value for White Leghorns was calculated to be 3.4 +/-0.19 mgm./kg., for turkeys to be 5.9 +/- 0.72 mgm./kg., and for Japanese quail to be 16.5 +/- 0.56 mgm./kg., body weight. The dose-response curves are linear and parallel through one standard deviation on either side of the LD50 when log-dose is plotted against probit for survivors. It is suggested that the mechanism of action of ochratoxin A is similar in the three species, though the potency differs. The reduction in weight gain of Leghorn survivors was proportional to dose, and was observed in two separate traials over an overall dosage range from 0.2 mgm./kg. to 5 mgm./kg. The turkeys showed only a slight reduction in weight gain at doses less than 4mgm./kg., a more marked reduction being observed at higher dose levels. The quail did not show reduction of weight gain at dose levels below 10.9 mgm./kg., though the reduction was proportional to dose at higher levels. All birds dying of acute ochratoxicosis revealed a progression of symptoms from listlessness, huddling, occassionally diarrhoea, ataxia, prostration and death. Viscereal gout was observed at necropsy of the Leghorns.
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PMID:Acute oral ochratoxicosis in day-old White Leghorns, turkeys and Japanese Quail. 93 32

Mufangji Decoction is a famous herbal formula from Synopsis of Golden Chamber. However,it is easy to be misunderstood due to so its unique compatability. The syndromes treated by Mufangji Decoction included the following aspects:(1) in terms of modern medicine,it could be used to treat acute and chronic heart failure,heart failure aggravated by lung infection,chronic obstructive pulmonary disease acute episode,pulmonary heart disease,bilateral pleural effusion,acute attack of gout,rheumatic fever,rheumatoid arthritis,and rheumatoid arthritis;(2) in terms of symptoms,it could be used to treat asthma,chest tightness,wheeze impacting prostration and dyspnea impacting sitting posture; gastric distention; dark face,cyanotic,and mitral valvular face; edema of head and extremities; dry mouth,thirsty,unwilling to wear thick clothes,intolerance of heat,and irritable; fatigue,shortness of breath,poor appetite,constipation,less urine,yellow color,poor response to diuretics,and diuretic resistance; fast heart rate,which is hard to be controlled by Western medicine and has no response to Zhenwu Decoction; dark red tongue,dry tongue with yellow fur,rapid pulse,or deep tight pulse. In emergency and severe cases,Yang deficiency and fluid retention are normal syndromes of heart failure,while Yang deficiency,fluid retention,and heat are metamorphic syndromes of heart failure,which possessed complex mechanisms of pathophysiology; the mechanisms of Shaoyin heat-conversion syndrome is similar to Yang deficiency,fluid retention,and heat syndrome; the reason of application of gypsum in Mufangji Decoction shall be further studied; the " empty" and " real" in modified Mufangji Decoction are physical signs,rather than pathogenesis.
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PMID:[Mufangji Decoction formula tracing and its effect on emergency and severe cases]. 3098 62