Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and two consecutive patients receiving maintenance hemodialysis were interviewed and examined to analyze their musculoskeletal problems. Radiographic abnormalities of renal osteodystrophy were found in 23 and there were periarticular calcifications in 5. Only one patient had apatite associated knee arthritis and none had gout or calcium pyrophosphate deposition disease. Twenty patients had arthralgias, 3 polyarthritis, and 4 knee effusions all of which were incompletely explained. Correlations of arthralgias with radiographic findings was poor. Muscle cramps were seen in 24 patients, multiple fractures in one, symmetrical distal neuropathy in 18, and carpal tunnel syndrome in 9.
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PMID:Musculoskeletal manifestations in hemodialysis patients. 409 22

Patients with parathyroid disease can have important musculoskeletal problems.Hypoparathyroidism can cause subcutaneous calcifications, tetany, muscle cramps,and paresthesias, but also myopathies and an ankylosing spondylitis-like back disease. Hypoparathyroidism can occur in SLE caused by antiparathyroid antibodies.Patients with hyperparathyroidism can develop bone disease with cysts, erosions,and deformities. They can also develop pseudogout, gout, myopathies, and tendon ruptures.
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PMID:Parathyroid disease. 2109 44