Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cross-sectional associations between biological, clinical and behavioral factors and serum uric acid (SUA) levels were examined in 2,438 Japanese male office workers aged 20 to 59 years in Osaka, Japan. Stepwise regression analysis for SUA was carried out for all persons and repeated excluding those under medication for hypertension, hyperuricemia or diabetes mellitus. The results were essentially the same without change in the sequence of the seven most important variables. When 150 men under medication were excluded, independent correlates with SUA levels were, in order of relative importance, history of gout, log triglyceride, creatinine, hemoglobin A1c (negative association), body mass index, total protein, alcohol intake, age (negative association), and total cholesterol. 32.7 percent of total variation in SUA was accounted for by these variables combined. Our data suggest that weight and serum lipids control and avoiding excessive drinking may be beneficial in the prevention of hyperuricemia.
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PMID:Serum uric acid: correlation with biological, clinical and behavioral factors in Japanese men. 1033 82

Uric acid (UA), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. However, an abnormal UA concentration may be connected with many diseases: a higher UA concentration, comings from improper lifestyle such as purine excessive intake and excessive drinking, may reveal hyperuricemia, gout and some cardiovascular diseases; meanwhile, some genetic diseases can result in a low level UA relatively for a long time. Therefore, to develop a rapid and accurate detection method of UA is urgent and important. Recently many detection methods have been developed to measure the level of UA in human serum and urine sample even saliva and nails and tears. This review outlines the importance of UA detection and the history of the development of UA detection methods. UA detection include spectral (ultraviolet absorption, fluorescence), electrochemical (voltammetry, electrochemiluminescence, surface plasmon resonance), chromatography (liquid and gas phase), capillary electrophoresis and isotope dilution mass spectrometry, etc. Most of the above detection methods contain both enzymatic and nonenzymatic strategies. The materials used in mentioned methods above tend to be diversified, hence an overview of materials used in UA detection are also reported.
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PMID:Recent Progress on Uric Acid Detection: A Review. 3129 22