Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A familial predisposed diffuse nephropathy is described in three adult patients--brothers, combined with hearing abatement--receiver type--in two of them. Typical gout was also found in them, that is difficult to associate with the azotemia. It was admitted that it concerns the Alport syndrome in adults, developing with certain peculiarities, advanced patient age, disturbances of purine metabolism, moderately selective proteinuria of glomercultubular type and chromosome aberration--thresomia of F chromosome.
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PMID:[Hereditary nephritis with bearing loss of the receiver type (Alport's syndrome) with a description of 2 cases]. 446 73

Allopurinol (4-hydroxypyrazolo (3,4-d)-pyrimidine) is a potent xanthine oxidase inhibitor which inhibits the oxidation of naturally occurring oxypurines, thus decreasing uric acid formation. The clinical and metabolic effects of this agent were studied in 80 subjects with primary and secondary gout and other disorders of uric acid metabolism. Allopurinol has been universally successful in lowering the serum uric acid concentration and uric acid excretion to normal levels, while not significantly affecting the clearance of urate or other aspects of renal function. Oxypurine excretion increased concomitantly with the fall in urine uric acid. The agent is particularly valuable in the management of problems of gout with azotemia, acute uric acid nephropathy and uric acid urolithiasis. The minor side effects, clinical indications and theoretical complications are discussed.
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PMID:The treatment of gout and disorders of uric acid metabolism with allopurinol. 592 71