Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to explore the prevalence of tobacco and alcohol use and to determine the factors associated with tobacco and alcohol use among chronic disease patients in Cambodia, Myanmar and Vietnam. A cross-sectional survey was conducted among 4,803 adult chronic disease patients (mean age 49.3 years; SD=16.5) recruited systematically from health facilities. Fifteen point five percent of those studied were current smokers, 14.5% current smokeless tobacco users, 20.7% daily tobacco users (smokers or smokeless tobacco), 9.3% problem drinkers and 4.1% both daily tobacco users and problem drinkers. Having been diagnosed with hypertension, chronic obstructive pulmonary disease (COPD), liver disease, and dyslipidemia were positively associated with daily tobacco use; liver disease, gout and other musculoskeletal conditions, kidney disease, and dyslipidemia were positively associated with problem drinking. On multivariate logistic regression analysis, socio-demographics (being male, older age, lower education, coming from Myanmar, being single, divorced or widowed, rural residence and part-time employed), problem drinking and having two or more chronic health conditions were associated with daily tobacco use. Socio-demographics (being male, younger age, coming from Vietnam, being married or cohabiting), daily tobacco use and not having depressive symptoms were found to be associated with problem drinking. High prevalences of daily tobacco use and problem drinking were found among chronic disease patients and several socio-demographic, disease specific, and other health risk behavior factors were identified which can guide substance use intervention programs for this population.
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PMID:TOBACCO AND ALCOHOL USE AMONG CHRONIC DISEASE PATIENTS IN CAMBODIA, MYANMAR AND VIETNAM. 2740 38

Habitual coffee and caffeine consumption has been reported to be associated with numerous health outcomes. This perspective focuses on Mendelian Randomization (MR) approaches for determining whether such associations are causal. Genetic instruments for coffee and caffeine consumption are described, along with key concepts of MR and particular challenges when applying this approach to studies of coffee and caffeine. To date, at least fifteen MR studies have investigated the causal role of coffee or caffeine use on risk of type 2 diabetes, cardiovascular disease, Alzheimer's disease, Parkinson's disease, gout, osteoarthritis, cancers, sleep disturbances and other substance use. Most studies provide no consistent support for a causal role of coffee or caffeine on these health outcomes. Common study limitations include low statistical power, potential pleiotropy, and risk of collider bias. As a result, in many cases a causal role cannot confidently be ruled out. Conceptual challenges also arise from the different aspects of coffee and caffeine use captured by current genetic instruments. Nevertheless, with continued genome-wide searches for coffee and caffeine related loci along with advanced statistical methods and MR designs, MR promises to be a valuable approach to understanding the causal impact that coffee and caffeine have in human health.
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PMID:Mendelian Randomization Studies of Coffee and Caffeine Consumption. 3024 58