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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. A commercial 62-week-old layer flock experienced an acute drop in egg production and an increase in shell-less egg production within 2 days of consuming feed erroneously formulated to contain over 30 g/kg instead of 3 g/kg sodium bicarbonate (NaHCO3). Other symptoms included increased water consumption, diarrhoea and increased mortality associated with visceral gout. 2. An experiment was conducted to assess the responses of hens under controlled conditions. Twenty Dekalb XL Single Comb White Leghorn hens (50 weeks old) were placed in individual cages, having ad libitum access to water from trough waterers. Ten hens were fed the TEST (High NaHCO3) feed for one week (Test group), and ten hens remained on normal commercial layer ration (Control group). 3. Hens in the Test group had high water consumption and watery droppings, but egg production and mortality were not affected. Physiological evaluations indicated the Test feed caused metabolic alkalosis. Plasma sodium, urine pH and urinary sodium excretion were increased, and glomerular filtration rates were decreased in the Test group. 4. These physiological effects are consistent with known responses to excess sodium intake in domestic fowl. The reduced egg production and increased mortality caused by the Test feed under commercial conditions may be related to more severe dehydration experienced by hens in multi-bird cages supplied by cup-type watering systems.
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PMID:Excess sodium bicarbonate in the diet and its effect on Leghorn chickens. 132 26

A 55-year-old woman was referred to our ward for further evaluation of marked hyperuricaemia and suspected tophi. On physical examination, huge subcutaneous nodules were observed on the knee joints as well as a small nodule on the lateral side of the left sole. Blood chemistry showed marked hyperuricaemia (0.85 mmol/l), hypokalaemia (2.7 mmol/l) and a mild degree of renal insufficiency. Arterial blood gas analysis showed signs of metabolic alkalosis. Daily urinary uric acid excretion on a purine non-restricted diet was 8.9 mmol/day. Uric acid clearance and fractional uric acid clearance were 0.8 ml/min and 2.6%, respectively. Plasma renin activity was 21.8 ng/ml/h, and plasma angiotensin II and aldosterone concentrations were 61 and 121 pg/ml, respectively. However, pressor response to an intravenous administration of angiotensin II was normal. The urinary calcium to creatinine molar ratio was 0.069, and serum magnesium concentration was normal to supranormal. A biopsy of the subcutaneous nodule showed a typical appearance of tophus. Based on these findings, the patient was diagnosed with an atypical case of renal tubular hypokalaemic metabolic alkalosis, with marked hyperuricaemia and tophi as the initial manifestations. So far, only four cases of Bartter's syndrome with gout and/or hyperuricaemia have been described in Japan. This rare case is presented and its mechanism of hyperuricaemia discussed.
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PMID:An atypical case of primary renal tubular hypokalaemic metabolic alkalosis with chronic tophaceous gout. 1164 22

A 32-year-old woman with pseudo-Bartter syndrome secondary to excessive use of laxatives, presented with hypokalemia, metabolic alkalosis, hyperuricemia, and gouty arthritis with tophi. Subsequently the patient became pregnant and displayed recurrent severe gouty flares of multiple joints. Monosodium urate crystals were aspirated from the knee confirming the diagnosis of gout. Previous reports have stated an association between Bartter syndrome and gout, but this is the first case report of a pregnancy with active gouty arthritis combined with pseudo-Bartter syndrome.
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PMID:Pregnancy in a patient with gouty arthritis secondary to pseudo-Bartter syndrome. 2066 Oct 67

A total of 60, 3-week-old, laying pullets were used in the present experiment. The exposed birds received excess sodium bicarbonate (SB) in their drinking water for 35 days at the levels of: 2 g/l (0.2%), 7.5 g/l (0.75%), 20 g/l (2%) and 40 g/l (4%). All birds were subjected to pathological and toxicological examination. Birds of the 0.75% and 2%-groups developed gross picture of visceral gout, while birds of 4%-group showed acute kidney damage without manifesting visceral urate deposition. Erythrocytic count, packed cell volume (PCV), and hemoglobin (Hb) levels were all increased in the exposed birds. There were dose-related increments in the serum level of sodium (Na(+)). Serum levels of chloride (Cl(-)), and potassium (K(+)) were relatively decreased in some cases. Serum levels of uric acid were increased in a dose-related pattern. Blood pH of the treated birds was shifted toward the alkaline side. Microscopic examination revealed significant renal changes in birds manifesting visceral gout and these changes included urate deposits associated with tubular necrotic changes. Some birds in the third group (2%) developed urate granulomas (tophi) in their renal interstitium. It was concluded that development of gout in birds may be related to a state of metabolic alkalosis which is associated with significant changes of the electrolyte balance.
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PMID:Toxopathology of gout induced in laying pullets by sodium bicarbonate toxicity. 2178 31