Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although the classic location of gouty tophi is the great toe (podagra), gouty tophi of the ear also is common and is worth including in the differential diagnosis in patients presenting with ear lesions. Other entities presenting as papules or nodules on the ear include chondrodermatitis nodularis helicis (CNH), actinic keratosis, basal cell carcinoma, squamous cell carcinoma, verruca vulgaris, amyloids, rheumatoid nodules, and elastotic nodules. If tophaceous gout is suspected, alcohol fixation of the biopsy specimen is preferable, as it enables visualization of characteristic needle-shaped urate crystals.
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PMID:Gouty tophi on the ear: a review. 2419 91

Gout tophi around auricular area are common in old men. The differential diagnosis of papules or nodules on the ear includes tophaceous gout, rheumatoid nodules, basal or squamous cell cancer, melanoma, verruca vulgaris or actinic keratosis. The presence of the skin cancer, most commonly located on the head and neck, is often related to the long exposure of the skin to sunlight. Elderly patients are the predominant group of patients with skin malignancies. The aim of this study is to emphasize the importance of early cancer detection in elderly people and use of appropriate therapeutic options that take into account the special requirements of geriatric patients. In this article the case of a 91-year-old man with advanced gout and squamous cell cancer of the skin of the ear, treated radically with a positive clinical effect, is presented. Moreover, the diagnostic and therapeutic problems are presented.
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PMID:[Gout or squamous cell cancer of the ear in a 91-year-old man - diagnostic and therapeutic problems: a case report]. 2955 58