Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The connections between venous disorders and osteoarticular or rheumatic diseases are common and varied, and it is important to know about therapeutic incidence. Several clinical patterns emerge from this interrelated pathology: --the point of interest in the venous symptoms of gout seems to be shifting towards the more concrete context of phlebopathies associated with hyperuricemic conditions; --venous anomalies, accompanied by osteal reactions, are interesting from a clinical point of view whilst apparently at the limits of therapeutic possibilities; --the introduction of per-trochanteric phlebography marks a new chapter in the understanding of the pathogeny and therapy of coxarthritis; --the common association of venous insufficiency with arthritic seizure in the knee calls primarily for phlebological treatment and hydromineral cures; --these morbid associations clearly indicate a need for increasingly close cooperation between phlebologists and rheumatologists.
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PMID:[Venous disorders associated with osteoarticular and rheumatoid diseases: therapeutic occurrence]. 746 42

Cellulitis is a bacterial skin and soft tissue infection which occurs when the physical skin barrier, the immune system and/or the circulatory system are impaired. Diabetes, obesity and old age are associated with defects in all of these areas and as a result are major predisposing factors for cellulitis. In this review, we summarise current insights into the pathophysiology of cellulitis and place the Dutch guidelines on the clinical management of cellulitis of the lower extremities in perspective. Recent evidence on diagnostic strategies is discussed, the importance of which is underscored by findings that venous insufficiency, eczema, deep vein thrombosis and gout are frequently mistaken for cellulitis. Empiric antibiotic choices are designed against the background of a low prevalence of multi-resistant Staphylococcus aureus. Novel antimicrobial agents registered for cellulitis are also discussed. Relapses occur frequently due to a high prevalence of risk factors associated with cellulitis in combination with the ccurrence of persistent post-inflammatory lymphatic damage. Lastly, we identify knowledge gaps which, if addressed, will advance our understanding of the pathophysiology of cellulitis and improve its clinical management.
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PMID:Cellulitis: current insights into pathophysiology and clinical management. 2921 14