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Target Concepts:
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Query: UMLS:C0018099 (
gout
)
5,192
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aristolochia
herbals have a 2500-year history of medicinal use. We focused this article on Portland's Powders, an 18
th
-century British
gout
medicine containing
Aristolochia
herbs. The powders constitute an 18
th
-century iteration of an herbal remedy, which was used, with variations, since at least the fifth century BCE. The use of Portland's Powders in Great Britain may appear to be an unusual choice for investigating a public health problem currently widespread in Asia. Yet it exemplifies long-term medicinal use of
Aristolochia
herbs, reflecting our argument that aristolochic acid nephropathy (AAN) is a historically persistent
iatrogenic disease
. Moreover, we provide compelling evidence that individuals taking Portland's Powders for
gout
would have ingested toxic quantities of aristolochic acid, which causes AAN and cancer. Several factors, including long history of use, latency of toxic effects, and lack of effective regulation, perpetuate usage of
Aristolochia
herbals to the present day.
...
PMID:
Aristolochia
Herbs and Iatrogenic Disease: The Case of Portland's Powders. 3260 94
