Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018099 (gout)
 5,192 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Part II of the cutaneous deposition disorders focuses on cutaneous calcification and ossification, alkaptonuria and ochronosis, and gout. These disorders have in common the deposition of materials in the dermis or subcutis and often involve metabolic defects in hormonal and enzymatic regulation. The pathogenesis, clinical findings, and treatment of these diseases are discussed. Both the histologic and ultrastructural findings are reviewed.
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PMID:Cutaneous deposition diseases. Part II. 977 59

Two rheumatic diseases can often coexist despite the interesting fact that gout and rheumatoid arthritis (RA) are infrequently associated. We describe a patient with familial history of alkaptonuria and rheumatoid arthritis who developed both diseases. The exact time of onset of the RA was difficult to ascertain. The RA seemed to be rapidly progressive, possibly because of the delayed recognition, overly cautious drug treatment, or additive effects of the two diseases. Physicians should keep in mind the possible coexistence of two joint diseases in patients who are not doing well.
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PMID:Coexistence of ochronosis and rheumatoid arthritis: a cause of delay in diagnosis and treatment. 1907 74