Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Expression level of long non-coding RNA (lncRNA)
RHPN1
-AS1 in
glioma
tissues was detected to determine potential risk factors influencing prognosis of
glioma
. This study aimed to clarify the molecular mechanisms underlying tumorigenesis of
glioma
and thus to improve therapeutic efficacy of
glioma
.
RHPN1
-AS1 levels in
glioma
tissues (n=105) and normal brain tissues (n=105) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between
RHPN1
-AS1 level and pathological indicators of
glioma
patients was analyzed.
Glioma
patients were followed up for 5 years. Overall survival (OS) and relapse-free survival (RFS) in
glioma
patients were tested by Kaplan-Meier and log-rank method. Potential factors influencing prognosis of
glioma
were analyzed by Cox regression model.
RHPN1
-AS1 was upregulated in
glioma
tissues. Its level was correlated to histological grade, Karnofsky (KPS) score and postoperative recurrence of
glioma
patients, rather than sex, age, pathological and tumor size.
Glioma
patients expressing high level of
RHPN1
-AS1 suffered worse OS and RFS than those with low level. Advanced histological grade, KPS score <80 and high level of
RHPN1
-AS1 were considered to be risk factors influencing postoperative prognosis of
glioma
. High level of
RHPN1
-AS1 is an independent risk factor for poor prognosis of
glioma
, which may be utilized as a prognostic hallmark.
...
PMID:Prognostic potential of lncRNA RHPN1-AS1 in glioma. 3278 61
