Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
staphylococcal nuclease and tudor domain containing 1
(
SND1
) is a multifunctional protein overexpressed in breast, prostate, colorectal and hepatocellular carcinomas and malignant
glioma
. Molecular studies have revealed the multifaceted activities of
SND1
involved in regulating gene expression at transcriptional as well as post-transcriptional levels. Early studies identified
SND1
as a transcriptional co-activator.
SND1
is also a component of RNA-induced silencing complex (RISC) thus mediating RNAi function, a regulator of mRNA splicing, editing and stability, and plays a role in maintenance of cell viability. Such diverse actions allow the
SND1
to modulate a complex array of molecular networks, thereby promoting carcinogenesis. Here, we describe the crucial role of
SND1
in cancer development and progression, and highlight
SND1
as a potential target for therapeutic intervention.
...
PMID:Role of the staphylococcal nuclease and tudor domain containing 1 in oncogenesis (review). 2540 67
