Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TPD52L2
(tumor protein D52-like 2) is a member of TPD52 family which has been implicated in multiple human cancers. Recently, TPD52 protein was shown to be associated with several malignancies, but very little is known about the function of
TPD52L2
in cancers, especially in
glioma
to date, and its roles in
glioma
occurrence and progression remain to be elucidated. In the present study, we employed lentivirus-mediated RNA interference (RNAi) to knock down
TPD52L2
expression in human
glioma
cell line U251. We found that knockdown of
TPD52L2
significantly not only inhibited cell proliferation and colony formation, but also induced G0/G1 cell cycle arrest in vitro. Taken together, these findings suggest that
TPD52L2
might play an important role in
glioma
tumorigenesis.
...
PMID:Lentivirus-mediated knockdown of tumor protein D52-like 2 inhibits glioma cell proliferation. 2484 31
