Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alpha thalassemia/mental retardation syndrome X-linked
(
ATRX
) is mutated in nearly a third of pediatric glioblastoma (GBM) patients. We developed an animal model of
ATRX
-deficient GBM. Using this model combined with analysis of multiple human
glioma
genome-wide datasets, we determined that
ATRX
mutation leads to genetic instability, impaired non-homologous end joining, and alternate lengthening of telomeres (ALT).
...
PMID:ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability. 2731 1
