Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
microRNAs (miRNAs) can function as a tumor suppressor or oncogenic genes in human cancers. Alternation expression of miR-199a-5p has been revealed in several human cancers. However, its expression pattern and biological roles in
glioma
remain unclear. Expression levels of miR-199a-5p in
glioma
were evaluated at first. The effects of miR-199a-5p expression on cell proliferation, migration, and invasion were investigated using the MTT assay, wound-healing assay, and transwell invasion assay. The expression of miR-199a-5p was found to be reduced in
glioma
cell lines. Overexpression of miR-199a-5p inhibits
glioma
cell proliferation, migration, and invasion in vitro. Furthermore, the target of miR-199a-5p was predicted by TargetScan and validated by luciferase activity reporter assay. We found
magnesium transporter 1
(
MAGT1
) was a direct target of miR-199a-5p. Overexpression of
MAGT1
reversed the effects of miR-199a-5p on
glioma
cell behaviors. Taken together, our study revealed that miR-199a-5p and
MAGT1
have the potential to be used as a biomarker for
glioma
.
...
PMID:microRNA-199a-5p suppresses glioma progression by inhibiting MAGT1. 3103 61
