Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Long non-coding RNAs (lncRNAs) have been reported to play important roles in
glioma
; however, most of them promote
glioma
progression. We constructed a competing endogenous (ceRNA) network based on the Chinese
Glioma
Genome Atlas dataset, and lncRNA hect domain and RLD 2 pseudogene 2 (
HERC2P2
) is the core of this network. Highly connected genes in the ceRNA network classified the
glioma
patients into three clusters with significantly different survival rates. The expression of
HERC2P2
is positively correlated with survival and negatively correlated with clinical grade. Cell colony formation, Transwell and cell scratch tests were performed to evaluate the role of
HERC2P2
in glioblastoma growth. Furthermore, we overexpressed
HERC2P2
in U87 cells and established a mouse intracranial
glioma
model to examine the function of
HERC2P2
in vivo. In conclusion, we identified a lncRNA with tumor suppressor functions in
glioma
that could be a potential biomarker for
glioma
patients.
...
PMID:Identification of long non-coding RNA HERC2P2 as a tumor suppressor in glioma. 3080 32
