Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Malignant glioma is notorious for its aggressiveness and poor prognosis, and the invasiveness of
glioma
cells is the major obstacle. Accumulating evidence indicates that kinesin superfamily proteins (KIFs) may play key roles in tumor invasiveness, but the mechanisms remained unresolved. Our previous study demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) was involved in
Kinesin family member 1B
(
KIF1B
)-modulated invasion of gastric cancer cells. Therefore, the role of
KIF1B
in
glioma
cell invasion and its relationship with MT1-MMP were explored in the present study. We found that aberrantly increased expression of
KIF1B
was associated with worse WHO pathological classification and Karnofsky performance status (KPS), which also showed a trend towards worse prognosis. In the transwell assay, knockdown of
KIF1B
using siRNA repressed U87MG and A172
glioma
cell migration and invasion. Silencing
KIF1B
inhibited expression of membranal MT1-MMP; however, the amount of MT1-MMP in the whole cell lysate was not affected. In conclusion, targeting
KIF1B
may be an option for anti-invasive therapies targeting
glioma
.
...
PMID:KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. 2657 27
