Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Three new compounds and the known benzamides of 2-acetamido-
3-hydroxybenzamide
, 2-amino-
3-hydroxybenzamide
, and 2-aminobenzamide were isolated from the culture of a marine actinomycete
Streptomyces
sp. ZZ502. Structures of the new compounds were determined as 3-amino-2-carboxamine-6(
R
)-chloro-4(
R
),5(
S
)-dihydroxy-cyclohex-2-en-1-one, 3-amino-2-carboxamine-4(
S
),6(
S
)-dihydroxy-cyclohex-2-en-1-one, and 3-hydroxy-2-propionamidobenzamide based on extensive NMR spectroscopical analysis, HRESIMS data, ECD calculation, and X-ray diffraction analysis. None of these isolated compounds showed activity in inhibiting the proliferation of
glioma
cells nor the growth of methicillin-resistant
Staphylococcus aureus
,
Escherichia coli
, and
Candida albicans
.
...
PMID:Novel cyclohexene and benzamide derivatives from marine-associated
Streptomyces
sp. ZZ502. 3041 73
