Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four oxidovanadium(IV) complexes, [VO(hntdtsc)(phen)] (1), [VO(hntdtsc)(bpy)] (2) (hntdtsc=2-hydroxy-1-naphthaldehyde thiosemicarbazone, phen=1,10-phenanthroline), [VO(satsc)(phen)] (3) and [VO(satsc)(bpy)] (4) (satsc=salicylaldehyde thiosemicarbazone, bpy=2,2'-bipyridine) have been synthesized and characterized. The results show that complexes 1, 2, 3 and 4 interact with DNA through intercalative mode and can efficiently cleave the plasmid pBR 322 DNA. It is interesting to note that these four complexes present highly cytotoxic activities against Myeloma cell (Ag8.653) and Gliomas cell (U251) lines. Complex 1 was found to be the most potent antitumor agent among the four complexes.
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PMID:Synthesis and characterization of unsymmetrical oxidovanadium complexes: DNA-binding, cleavage studies and antitumor activities. 2254 85