Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Our previous studies with various cell lines and human glioma cells showed that glycerol suppresses cell proliferation. In this study, we examined the effects of glycerol on the cytoskeleton, general morphology and attachment of Baby Hamster Kidney (BHK) cells. In glycerol-treated cells proliferation was suppressed, the microfilament network was extensively reorganized and the microtubule network was more clearly defined, while the cell thickness, as observed by scanning electron microscopy (SEM), was decreased. In addition, glycerol treatment resulted in an increase in the number of nucleoli per cell and in the appearance of non-mitotic rounded cells. Glycerol treatment increased the time needed to trypsinize BHK cells from the culture dishes and reduced the time required for cell reattachment. We suggest that glycerol treatment provides a non-toxic tool to examine mechanisms of proliferation arrest.
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PMID:Glycerol alters cytoskeleton and cell adhesion while inhibiting cell proliferation. 151 37

In some cases of glioma, it may be relatively difficult to demonstrate by computed tomography (CT), or even by contrast enhancement technique (CE). Studying a series of delayed CT scans, it seems that one of the main factors of delayed CE effect is due to extravascular components of iodine. So for getting better CE effect in these gliomas, we tried to increase the extravascular iodine concentration with utilizing the returning water of intravenously administrated Glycerol. By this method of drip injection of contrast material following the Glycerol, we could get an increase of CE effect of 40 or 70% comparing to the usual drip injected CE scans in two benign gliomas, but we couldn't find the difference in one malignant glioma and in the high vascular area of the benign gliomas. Though the mechanism was not completely explained in this article, we thought that CE effect in malignant gliomas or high vascular tumors was mainly by intravascular component of iodine. This malignant glioma a big cyst, and with the use of intravenous contrast material and delayed CT scanning, we had been able to know that contrast media entered cystic collections, which progressively increased in density and were maximally enhanced on delayed, 180 minutes after injection of contrast material.
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PMID:[A role of glycerol in contrast enhancement (author's transl)]. 724 92