Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017638 (glioma)
 30,880 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of memantine on several properties of a neuronal cell line was tested. The aim was to get some insight into possible mechanisms of action of this drug which is therapeutically applicable in treatment of spasticity, Parkinson's disease, and cerebral coma. In neuroblastoma X glioma hybrid cells, memantine, at micromolar concentrations, blocked the depolarization induced by iontophoretically applied serotonin (5-hydroxytryptamine, 5-HT). In the hybrid cells, receptors of the 5-HT3 type mediated the depolarization, which was frequently accompanied by a series of action potentials. The inhibition by memantine of the serotonin response occurred fast and was completely reversible, irrespective of whether the cell showed a stable membrane potential or spontaneous action potentials. However, memantine did not alter spontaneous or electrically evoked action potential activity in the hybrid cells, and apparently did not block the underlying ionic conductances. Furthermore memantine did not affect either the cation permeability activated by substance P in the hybrid cells or the K+ channel triggered by bradykinin in a glioma cell line. Thus, memantine appears specifically to suppress the ion channel opened by serotonin in the hybrid cells. The interaction of memantine with serotonin receptors and the associated ion channels reported here, might give an important clue, as to a site of action of memantine in the nervous system.
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PMID:Memantine (1-amino-3,5-dimethyladamantane) blocks the serotonin-induced depolarization response in a neuronal cell line. 335 74

Brainstem gliomas are neoplasms primarily affecting children. Depending on the type, they usually present with varying combination of multiple bilateral or unilateral cranial nerve palsies, long-tract signs, ataxia and sometimes hydrocephalus. Though movement disorders have been reported in association with basal ganglia and thalamic tumours, hemi-chorea, as a presentation of brainstem glioma, has not been reported till date. I present a case of a 9-year-old female child, who presented with complaints of difficulty in walking and involuntary movements affecting the left upper and lower limb. On examination, she had chorea involving left side of the body, bilateral lateral rectus palsy, with spasticity of right upper and lower limb. CT scan and MRI of the brain showed focal glioma involving the upper pons and midbrain. The patient underwent surgery in the form of sub-occipital craniotomy and tumour removal. Postoperative imaging studies showed no residual tumour. Histopathological examination was suggestive of pilocytic astrocytoma grade 1. Postoperatively hemi-chorea decreased in intensity, but did not disappear completely.
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PMID:Hemi-chorea: an unusual presentation of brainstem glioma. 2317 Nov 49