Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017638 (
glioma
)
30,880
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tectonic-1, also named as
TCTN1
or TECT1, which belongs to a family of signal-sequence-containing secreted and transmembrane proteins evolutionarily conserved among eukaryotes, was reported to be involved in central nervous system development and ciliogenesis. In this paper, we found that
TCTN1
is extensively expressed in human
glioma
cell lines. To clarify the role of
TCTN1
in
glioma
, we employed lentivirus-mediated short hairpin RNA to knock down
TCTN1
expression in U251 and U87MG
glioma
cells. Knockdown of
TCTN1
potently inhibited cell proliferation, as determined by MTT and colony formation assays. Cell cycle analysis showed depletion of
TCTN1
led to both U251 and U87MG cells arrested in the G0/G1 phase. These data suggest
TCTN1
is essential for
glioma
cell viability, and dysregulation of
TCTN1
may play a key role in
glioma
tumorigenesis.
...
PMID:Lentivirus-Mediated Knockdown of TCTN1 Inhibits Glioma Cell Proliferation. 2573 23
